Table of Content

10 December 2014, Volume 12 Issue 4 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Select

Characteristics of rpoB and katG gene mutation in drug-resistant Mycobacterium tuberculosis in Lu'an area Chang Hongwei1 Li Kaichun1, Ma Tai1, Yang Wei1, Zhangfeng1, Zhang Limei1, Sun Lin2, Li Juan3, Li Wei4 2014, 12 (4):  187-189,193.  doi: 10.3969/j.issn.1672-2302.2014.04.001 Abstract ( 2296 )   Objective To investigate the characteristics of mutations in the rpoB and katG genes(clinical isolates) leading to drug- resistance in Mycobacterium tuberculosis(M. tuberculosis) in Lu’an area. Methods Drug sensitive test was performed in 65 strains of M. tuberculosis clinically isolated from the sputum samples collected in Lu'an area, and the gene fragments of rpoB and katG were amplified with specific primers, sequenced and analyzed. Results Of the 60 strains of M. tuberculosis, 9 were mutations involved in resistance against isoniazid, 14 against rifampin, and 6 against both. The mutation for the 4 in 9 isoniazid-resistant strains(katG gene) occurred at codon 315(codon change from AGG to ACC or ACA, 44.4%), and 11 of 14 rifampin resistant strains(rpoB gene) occurred at codon 516(GAC→GTC), 526(CAC→CGC or TAC) and 531(TCG→TTG,78.6 %). Five in 6 strains resistant to both isoniazid and rifampin had mutations, which accounted for 83.3%.Conclusion Drug-resistance M. tuberculosis in Lu’an area is associated with katG and rpoB gene mutation,in which the katG gene primarily occurs at codon 315(AGC→ACC or ACA), and the rpoB at 516(GAC→GTC), 526(CAC→CGC or TAC) and 531(TCG→TTG).   Related Articles | Metrics

Select

Therapeutic efficacy of combined moxifloxacin for drug-resistant pulmonary tuberculosis Ling huayu1, yang zhong 2014, 12 (4):  190-193.  doi: 10.3969/j.issn.1672-2302.2014.04.002 Abstract ( 2451 )    Objective  To observe the efficacies and safety of combined use of moxifloxacin in drug-resistant pulmonary tuberculosis. Methods  Sixty-two patients with drug-resistant pulmonary tuberculosis were randomly divided into treatment group and control group. The treatment group received additional moxifloxacin and the control group were given extra levofloxacin on the conventional amikacin, p-aminosalicylic acid, protionamide and cycloserine basis. The treatment duration lasted for 21 months, including injection for 6 months and oral use of the drug in 21 months. The entire treatment was carried out under surveillance of the providers during the hospital stay or follow up care. Results  By the end of injection treatment, negative conversion rate by sputum smear examination and sputum culturing was 78.1% for the treatment group and 46.7% for the controls, compared to 93.7% and 83.3% during the period of oral administration. X-ray imaging revealed that lesion absorption was excellent for 58% of the treatment group and 53% for the controls, and effective absorption rate were 90.1% and 80.0%, respectively. Conclusion  Combined moxifloxacin with amikacin, p-aminosalicylic acid, protionamide and  cycloserine can be effective and safe for drug-resistant pulmonary tuberculosis, with better negative conversion rate and lesion absorption. 【Key words】【Abstract】 Objective  To observe the efficacies and safety of combined use of moxifloxacin in drug-resistant pulmonary tuberculosis. Methods  Sixty-two patients with drug-resistant pulmonary tuberculosis were randomly divided into treatment group and control group. The treatment group received additional moxifloxacin and the control group were given extra levofloxacin on the conventional amikacin, p-aminosalicylic acid, protionamide and cycloserine basis. The treatment duration lasted for 21 months, including injection for 6 months and oral use of the drug in 21 months. The entire treatment was carried out under surveillance of the providers during the hospital stay or follow up care. Results  By the end of injection treatment, negative conversion rate by sputum smear examination and sputum culturing was 78.1% for the treatment group and 46.7% for the controls, compared to 93.7% and 83.3% during the period of oral administration. X-ray imaging revealed that lesion absorption was excellent for 58% of the treatment group and 53% for the controls, and effective absorption rate were 90.1% and 80.0%, respectively. Conclusion  Combined moxifloxacin with amikacin, p-aminosalicylic acid, protionamide and  cycloserine can be effective and safe for drug-resistant pulmonary tuberculosis, with better negative conversion rate and lesion absorption. Related Articles | Metrics

Select

Effect of clinical pathway management on imported malaria cases Li Xiaoli, Zou Yang, Wang Fei, Wang Lei, Feng Manling 2014, 12 (4):  194-197.  doi: 10.3969/j.issn.1672-2302.2014.04.003 Abstract ( 2551 )   Objective  To investigate effect of clinical pathway management on imported malaria cases.Methods  The data were collected in inpatients with malaria undergone treatment in Beijing Friendship Hospital Affiliated to Beijing Capital University between January 2011 and December 2012. All patients were divided into pathway management group (n=43, aged 25-56) and control group (n=37, aged 16-61). The two groups were evaluated regarding the length of hospital stay, medical costs, clinical outcomes and the extent of health knowledge as well as satisfaction with medical care. Results  In the pathway management group，average length of hospital stay was (6.1±1.5) d, whereas that for the control group was (8±2.1) d (P=0.000). Total costs in hospitalization for the pathway management group and control group were (2766±721) vs. (4 393±1 392)RMB yuan, the western medicine expenses (576±291) vs. (1145±597), laboratory cost (1 355±504) vs.(1 939±645), physical examination (109±16) vs. (445±73), treatment(73±22) vs. (104±43), respectively. The expense in pathway management group was significantly lower than that of control group(P<0.05). The patients in the pathway management group had better knowledge related to malaria and satisfaction with their medical care in hospital than their counterparts(P<0.05), yet the two groups remained similar concerning the clinical effect within 30 d and the unplanned readmission due to the same disease. Conclusion  Clinical pathway management can regulate medical behaviors through reduction of medical costs, avoidance of excessive laboratory tests and therapy, and is more conducive to care and healing of patients with malaria. Related Articles | Metrics

Select

Survey of the infection status of high-risk HPV and its related knowledge in women from entertainment establishments in Gaoqiao area She Qian, Liu Hong, Li Hua,Yi Liping 2014, 12 (4):  198-201.  doi: 10.3969/j.issn.1672-2302.2014.04.004 Abstract ( 2290 )   Objective  To investigate the infection status and human papillomavirus(HPV)related knowledge among women from entertainment establishments in Gaoqiao area in order to plan health education policies for this population group in scientific manner. Methods  By the systematic random sampling method, we conducted a survey on the females from some entertainment establishments with questionnaire and laboratory test. Women voluntarily received general check up on community basis were recruited as controls. Results  101 in 108 completed the questionnaire response and laboratory test, the results showed that 35.19% of the women working in the entertainment venues were in high-risk HPV status, whereas it was 15.84% for the ordinary women, the difference was significant. Only 16 (14.81%) and 17 (16.83%) in the two groups had indirect knowledge on HPV, and the difference was no significant. The perception was different between the two groups on the importance that whether she should undergo regular screening on the neoplasm if she had a family history of cervical cancer. However, there was no statistical difference pertaining to “whether the cervical cancer in early stage can be curable, or preventable; whether free sexual activity of self or her sexual partners would lead to cervical cancer; and ways to early identification of cervical cancer”. Conclusion  Women from entertainment establishments have higher infection rate of high-risk HPV, yet poorer perception on cervical cancer as compared with the ordinary women. Nevertheless, the two groups of women seem poorly on HPV related knowledge, suggesting that they should be given more health education on HPV in order to improve their awareness. Related Articles | Metrics

Select

Investigation on the deep fungal infection in children Zhang Qianqian1,Cheng Junzhen2 2014, 12 (4):  202-203,211.  doi: 10.3969/j.issn.1672-2302.2014.04.005 Abstract ( 2033 )   Objective To investigate the status of deep fungal infection in children, and analyze its sensitivity to first-line antibiotics for evidence to treat fungal infection. Methods The clinical data were retrospectively analyzed in 270 child inpatients with deep fungal infection undergone treatment in a hospital of Yanan area between March 2009 and December 2012. Antifungal susceptibility testing, including amphotericin B(AmB), fluconazole(FCZ), 5-flucytosine(5-FC) and itraconazole(ICZ) was performed in accordance with Clinical and Laboratory Standards Institute(CLSI) document M27-A2. Results The specimens obtained primarily using the nasopharyngeal swabs were isolated, and the results showed that Candida albicans was the highest(61.1%), followed by Candida glabrata,Candida tropicalis，Candida parapsilosis and Candida krusei. Drug sensitive test revealed that Candida albicans was highly sensitive to AmB and 5-FC. Conclusion Deep fungal infection is primarily associated with Candida, especially Candida albicans, and AmB and 5-FC have higher antifungal sensitivity. Surveillance shall be strengthened over the fungal infection and drug-resistance for reasonable use of antibiotics in clinic.  Related Articles | Metrics

Select

Sentinel surveillance in HIV/AIDS in adolescents in Hefei City from 2010 to 2013 Sun Jing 2014, 12 (4):  204-208.  doi: 10.3969/j.issn.1672-2302.2014.04.006 Abstract ( 2234 )   Objective  To investigate the HIV/AIDS-related knowledge, risk behavior and infective status of HIV, hepatitis C virus(HCV)and syphilis among adolescents in Hefei, Anhui Province, China, for effective policies for prevention and control of HIV/AIDS. Methods  By using multi-stage cluster sampling method, we conducted a survey on a total of 3244 adolescents living in Hefei area from 2010 to 2013 by self-response to anonymous questionnaire after obtaining the informed consent. Additional serological tests for HIV, HCV and syphilis were performed. Results  The correct response to HIV/AIDS-related knowledge was 81.8%, 86.1%, 82.6% and 85.7% in different age group. Awareness on "Whether mosquito bite will transmit HIV or not" ranked lowest in the 8 related questions. Of the total responders, 7.84% had sexual behavior in the past year. No more than 40% had ever used condom in their first sexual intercourse in our surveillance in four years, and lower than 50% insisted on using condoms in the last year in each sexual intercourse with either regular sexual partner, temporary sex partner or commercial sex partner. Only 2.7% had received HIV test in the past year, and generally, much fewer of the adolescents had ever received education on HIV/AIDS-related knowledge or voluntarily participated in spreading of HIV/AIDS-related knowledge. The serological finding revealed one case was positive to syphilis(0.03%) and 7, positive to HCV(0.2%) in the past years. Conclusion   Overall, the adolescents in Hefei area have a better knowledge on HIV/AIDS, yet they are poor in some individual awareness, and some of them have risk sexual behaviors and poor awareness on self-protection on HIV infection. More strength shall be laid on education, training and propaganda of this knowledge in this population group besides intervention with the high-risk behavior and wider coverage on HIV tests. Related Articles | Metrics

Select

Interferon α-2b and pegylated interferon α-2a in therapy of chronic hepatitis C patients with low viral load: Clinical observation on the rapid and early virological Xu Jing, Ou Yafei. 2014, 12 (4):  209-211.  doi: 10.3969/j.issn.1672-2302.2014.04.007 Abstract ( 2054 )    Objective  To observe the response of chronic hepatitis C patients with low viral load to antiviral treatment by different interferon(IFN) modality. Methods  120 patients with chronic hepatitis C were assigned to Peg-IFN group(n=58, treated with Peginterferon alfa-2a injection in dose of 180μg once a week) and recombinant human interferon α-2b injection group(n=62, administered in dose of 600 MU once every other day), and the two groups were given additional dosage of ribavirin by 900~1200 mg/d. The treatment course was as follows: 24 weeks were extended after rapid virological response(RVR), and 36 weeks after early virological response(EVR). For patients failed to meet EVR by the 12th week, 48 weeks were extended. The data were retrospectively analyzed on response to antiviral treatment, interferon modality and final viral load after treatment. Results  RVR and EVR were 79% and 85.4% for the patients treated with recombinant human interferon α-2b injection, and 81%, and 89.6 % for Peg-IFN group, respectively(χ2 = 0.009, P＞0.05; χ2 = 0.036, P＞0.05). There was no significance between groups regarding sustained virological response(SVR)(χ2 = 0.010, P＞0.05). Conclusion  Interferon α-2b and pegylated interferon α-2a may produce similar effects on chronic hepatitis C patients with lower viral load by statistical estimation of RVR, EVR and SVR. Related Articles | Metrics

Select

Surveillance and forecast and emergency management of schistosomiasis prevalence at the focal waters in Dantu district of Zhenjiang city Li Yefang1, Shen Xuehui1, Wang Hesheng1, Wang Lin2, Zhang Lianheng2, Chen Xiangping1 2014, 12 (4):  212-215.  doi: 10.3969/j.issn.1672-2302.2014.04.008 Abstract ( 2215 )   Objective  To understand the infectiion status of schistosome in water body of risk areas in order to early release the warnings and implement comprehensive measures to prevent the prevalence of acute schistosomiasis. Methods  The data were collected on the endemic status of schistosomiasis in Dantu District of Zhenjiang City from 2006 to 2008, and 6 surveillance sites were determined at the focal waters distributed in the towns of Dantu area. Surveillance was performed over the snail infestation, water infectivity, prevalence of miracidia of Schistosoma japonicum in the focal water body from May to September between 2009 and 2010, and the positive were released in timely manner. Emergency measures were implemented, including intensive monitoring over the water infectivity, investigation on the status of snail infestation and its eradication as well as health education. Results  Infested snails were free during the period of surveillance. A total of 1200 sentinel mouse were distributed, and 1126 were recovered(93.83%), in which 13 were found positive(1.15%). Three sites were potentially infested, and one site was suspected in consecutive 2 surveillances in June and July of 2010. 5 500 sentinel snails in 6 000 were recovered(91.67%), in which 3 311 received detection by the cercaria-shedding test, and showed no infections. Four times of warnings were released on the positive results. Screening examination of the 1 482 subjects contacted with the infested water by dipstick dye immunoassay (DDIA), positive results were found in 82(5.53%), and 7 were positive stools(0.47%). Seven in 169 herds of sheep were detected with infection(4.14%). A total of 15hm2 of water body within the monitoring sites were surveyed, where showed no snail infestation. Eradication of the snails and miracidia was performed respectively in 20hm2 and 11hm2 of water body. No single case of acute schistosomiasis occurred in two-year period of surveillance. Conclusion  Surveillance over the water body of risk areas may effectively control the incidence of schistosomiasis endemic through early warning and emergency management. Related Articles | Metrics

Select

Endemic trend and control effect of schistosomiasis in Jinhu County from 1970 to 2013 Li Qian, Sun Daokuan*, Wang Quanfeng 2014, 12 (4):  216-219.  doi: 10.3969/j.issn.1672-2302.2014.04.009 Abstract ( 2257 )   Objective To understand the endemic trend and control effect of schistosomiasis in Jinhu County, so as to explore schistosomiasis control strategy and control measures. Methods  The schistosomiasis control data in Jinhu County from 1970 to 2013 were collected, and the schistosomiasis prevalence, snail status and control strategy in different years and periods were analyzed retrospectively. Results  The control work of schistosomiasis in Jinhu County had been carried out since 1970, and the county belonged to mild endemic areas. After went through different control stages, namely transmission control, transmission interruption, and consolidation and monitoring, and position-relevant control strategies were taken, schistosomiasis in Jinhu County had been effectively controlled, and had reached the criteria of schistosomiasis transmission interruption in 1997, there had no local schistosome infection patients and domestic animals which were positive by fecal examination been found for 23 consecutive years. By the end of 2013, there were around 3 420.98hm2 snail infested areas found in 278 407.07hm2 investigated areas. The area with snail control by carrying out environmental modification and by using molluscicides was 60.96hm2 and 8 820.94hm2, respectively, and the area with snails had reduced by 99.64%. A total of 1 785 schistsosmiasis cases were found in 503 265 people, and a total of 397 head domestic animals were determined as schistosome infection in 41 114 ones. In addition, 2 795 schistosomiasis patients and 468 head of infected domestic animals were treated. Conclusion  Schistosomiasis in Jinhu County has been effectively controlled, but the emerging and reemerging snail area is occasionally discovered, and there are imported schistosomiasis cases, which may easily cause the revival of schistosomiasis transmission, so the surveillance and the control achievement consolidation should be strengthened. Related Articles | Metrics

Select

Current endemic situation of schistosomiasis in Wuwei County after reaching the criteria of infection control Sun Weibin, Cheng Huaisheng*, Wang Xiaoxiang, Yang Shizheng, Liujie 2014, 12 (4):  220-223,215.  doi: 10.3969/j.issn.1672-2302.2014.04.010 Abstract ( 2332 )   Objective  To understand the endemic situation of schistosomiasis in Wuwei County after reaching the criteria of infection control in 2008 so as to provide the evidence for decision-making of schistosomiasis control. Methods  The epidemiological data of schistosomiasis in Wuwei County from 2008 to 2013 were collected and analyzed with the descriptive epidemiology method. Results  By the end of 2013, there were 361 advanced cases of schistosomiasis, but no acute cases of schistosomiasis were found. There was still 2213.6694hm2 areas with Oncomelania snails in 2013, including 23.822hm2 areas in inland regions,1141.6694hm2 areas in marshland regions and 1048.1780hm2 areas in beach regions. No infected snails were found in recent two years, and the area of snail decreased obviously. A total of 816 head of cattle were raised in schistosomiasis transmission regions in 2013, and no infected cattle were found. A total of 30 villages in 7 towns reached the criteria of transmission control from 2008 to 2013. Conclusion  The endemic situation of schistosomiasis in Wuwei County declines obviously and maintains at lower level after reaching the criteria of infection control, and has reached the criteria of transmission control at present.   Related Articles | Metrics

Select

Alternative diluent used for the commercial IHA assay kit for detection of Schistosoma japonicum antibody Zhang Lesheng, Wang Enmu, Zhang Shiqing, Wang Qizhi, Hu Mingchuang, Si Wumin, Yang Rongsheng 2014, 12 (4):  224-226.  doi: 10.3969/j.issn.1672-2302.2014.04.011 Abstract ( 2083 )   Objective  To evaluate the feasibility of a new diluent as a substitute for the original ones (saline used for diluting the lyophilized sensitized red cells, and distilled water for diluting the serum specimen) packaged in the commercial indirect hemagglutination (IHA)assay kit manufactured by Anhui Anji Pharmaceutical Technology Co., Ltd. Methods  Phosphate buffered solution(PBS, pH7.2)was used to replace the diluent in the original kit, and two preparations were compared regarding the sensitivity and specificity in detection of Schistosoma japonicum as well as the cross-reactivity with liver fluke, lung fluke, giant intestinal fluke and hookworm. The minimal quantification and the agglutination pattern in each group were also observed. Results  The sensitivity and specificity were 95% and 96.9% for the modified kit, 94.2% and 95.8% for the original one, which suggested no significant difference(χ2=0.000, P=1.000). The Youden index were 0.92 and 0.9, respectively, and the minimum detectable amount was equal 1:1 280 to the two kits. However, PBS led to favorable agglutination pattern. The cross-reactivity rate with liver fluke, giant intestinal fluke and hookworm  was 0 and 19.4% with the lung fluke. Conclusion  It is feasible to replace the diluent in original kit with PBS as dilution for the modified IHA kit. Related Articles | Metrics

Select

Investigation on the second intermediate host(Potamon denticulate) of Paragonimus in Huangshan area   Fang Yimin1, Hu Xinsan2, Ling Zhili3, Wang Yebin1, Zhen Ruifeng1, Tang Yinong1, Bi Xianzhong1, Liu Daohua4, Guo Jianduo4 2014, 12 (4):  227-229.  doi: 10.3969/j.issn.1672-2302.2014.04.012 Abstract ( 2463 )   Objective  To investigate the infection status of Potamon denticulate, the second intermediate host of Paragonimus in Huangshan area in order to provide scientific basis for prevention and control of paragonimiasis. Methods  The survey sites were initially anchored according to the distribution nature of local water system and previous findings as well as local environment. Appropriate streams were selected, and the crabs were manually captured or harvested with a cage. The metacercariae of lung fluke were isolated in the lab under anatomical lens, and the infection rate of crabs and the infection index of metacercaria were calculated. Results  A total of 275 crabs were obtained in 12 administrative villages of 11 towns, and 57 were found infested with the Paragonimus(positive rate: 20.73%). The infectiosity was 3.51/per crab, and the metacercaria was counted as 0.958 in pergram of the infected crab. The infection index of metacercaria was 0.194 06. The prevalence and infectiosity were positively correlated with the weight of crab (r= 0.905, P<0.02; r= 0.929, P<0.01). The positive incidence and the infectiosity were higher in male crabs than in the female ones(χ2=136.53, P＜0.01), and the difference was significant for the positive incidence of crabs living in dissimilar rivers(χ2=7.70, P＜0.05). Conclusion  Our findings suggest that paragonimiasis is still endemic risks in Huangshan area, and Xin'an river basin shall be the focus of following paragonimiasis control. Related Articles | Metrics

Select

Investigation on Paragonimus infection status in elementary school students in the mountain areas of southern Anhui province Liu Daohua1, Wang Tianping1, Guo Jianduo1, Zhang Shiqing1, Fang Yimin2, Wang Yebing2. 2014, 12 (4):  230-232.  doi: 10.3969/j.issn.1672-2302.2014.04.013 Abstract ( 2098 )   Objective  To investigate the Paragonimus infection status and predisposing factors to this species in primary school students living in the mountain areas of southern Anhui province. Methods  By random cluster sampling method, we conducted a survey on 936 students in Huangshan City by obtaining the peripheral blood samples which were determined for the Paragonimus specific antibodies(IgM and IgG) by ELISA to examine the infection status. Besides, self-programmed questionnaire on the susceptibility to Paragonimus infection was performed to analyze risk factors. Results  The overall infection rate with Paragonimus was 12.07% (113/936), and varied significantly in students from different areas(P<0.05). Single factor analysis showed that the infection rate was dissimilar in different genders, and students with or without history of ingestion of crabs, intake of unboiled water or drinking water from different sources, as well as knowledge and awareness of Paragonimus infection(P<0.05). Conclusion  Higher infection rate with Paragonimus was found in the elementary school students living in Huangshan City, suggesting that this area remains endemic focus of this species. And prevention should be weighed on the male students, and those with habit of eating crabs and poor knowledge on Paragonimus infection, since they are susceptible population. Related Articles | Metrics

Select

Evaluation on schistosomiasis health education in workers of shipyards along the Yangtze River in Hexian County Ma Shichuan, Mao Yisong 2014, 12 (4):  233-234,244.  doi: 10.3969/j.issn.1672-2302.2014.04.014 Abstract ( 2292 )    Objective  To understand the effect of schistosomiasis health education on the knowledge and behavior in the migrant workers of shipyards along the Yangtze River in Hexian county. Methods  Three shipyards, built along the river beach within the endemic villages in Hexian county, were selected for pilot study by offering the worker with health education involved in schistosomiasis for consecutive three years. Then the migrant workers were surveyed on the knowledge related to schistosomiasis, their attitudes towards schistosomiasis prevention, incidences of actively contacting infested water and compliance with examination and treatment of schistosomiasis. Results  After consecutive three years of health education and behavior intervention, the awareness rate of schistosomiasis related knowledge, attitudes towards this disease prevention and the compliance with examination and treatment of schistosomiasis among the workers were increased from 11.2%. 9.1%, 38.8% and 31.7% to 93.8%, 91.9%, 93.2% and 84.3%, respectively, and the incidence of actively contacting the infested water was fallen from 6.8% to 0 after our efforts. No individual had ever been infected with schistosoma. Conclusion  Constant health education can improve the awareness of migrant worker on the risks and prevention of the schistosomiasis in endemic area, which has a positive effect on schistosomiasis control. Related Articles | Metrics

Select

Combined diagnosis of SAPHO syndrome by 99mTC-MDP bone imaging, X-ray and CT Yang Zhong, Xu Haiqing, Wu Bian, Song Liejing, Li Meng 2014, 12 (4):  235-237,253.  doi: 10.3969/j.issn.1672-2302.2014.04.015 Abstract ( 2127 )   Objective  To compare the image characteristic of SAPHO syndrome by X-ray and CT findings as well as 99mTC-MDP bone imaging for accurate diagnosis of this entity. Methods  The imaging property was examined on X-ray, CT and 99mTC-MDP bone imaging in 22 cases and compared with the advantages and disadvantages. Results  SAPHO syndrome presented distinctive features by different imaging technique, and the nature appeared prominent on X-ray and CT images, yet was more sensitive to 99mTC-MDP. Conclusion  Patients with suspected SAPHO syndrome may receive early examination by X-ray or CT, and additional nuclide bone imaging, as appropriate, may improve the diagnostic accuracy. Related Articles | Metrics

Select

Curative effect of Beifushu and Aikexin in treating residual burn wounds Yan Jong 2014, 12 (4):  238-240.  doi: 10.3969/j.issn.1672-2302.2014.04.016 Abstract ( 1930 )   Objective  To observe the therapeutic effect of combined Beifushu with Aikexin in treatment of residual burn wounds. Methods  The patients with residual burn wounds were included from January to December of 2013 and treated by Beifushu plus Aikexin with additional applying of 0.5% iodophor to the wounds, and the efficacies were compared with the control subjects. Results  The treatment group had shortened wound healing time(t=8.68, P<0.05), higher recovery rate at day 7, 14, 21 and 28(t=12.02, 8.56, 7.11, 5.49, respectively, P<0.05) and effective rate as compared with the controls(96.87% vs. 74.37%, χ2=3.96, P<0.05). Conclusion  Combined use of Beifushu with Aikexin for treatment of residual burn wounds may result in shortened healing time, effective control of the wound infection, facilitate early wound healing, reduction of pain and medical costs for the patients, suggesting that this regimen can be wider clinical use. Related Articles | Metrics

Select

Fasting blood glucose level and prognosis of patients with acute stroke Huang Qing, Yang Jie, Liu Chunmei, Zhou Junshan 2014, 12 (4):  241-244.  doi: 10.3969/j.issn.1672-2302.2014.04.017 Abstract ( 1692 )   Objective  To explore the relationship between fasting blood glucose level and prognosis for patients with acute stroke. Methods  699 consecutive patients with acute stroke were registered and included in the study. All patients underwent fasting blood glucose determination and quantification on the stroke severity based on National Institute of Health Stroke Scale (NIHSS) upon admission. A six-month prospective follow-up was performed in the eligible patients for the mortality and Modified Rankin Scale(MRS) was used to measure the degree of disability or dependence in the daily activities in the survivals. Multivariate logistic regression analysis was performed to determine the risk factors affecting prognosis of patients after stroke. Results The patients with history of diabetes had higher fasting blood glucose level, and accounted for a higher percentage in those with elevated level of fasting blood glucose. Although hyperglycemia was more frequent in patients with hemorrhagic stroke than those with ischemic stroke, yet the level was lower in patients with mild stroke than those with moderate stroke. Nevertheless, tendency of hyperglycemia remained no significant difference for those two groups of patients. The mortality at six-month was not significant between the patients with elevated blood glucose level and those with normal level, whereas patients with hyperglycemia were rated higher by the MRS. Multivariate logistic analysis showed that NIHSS>5 (OR=7.004, 95% CI: 4.490-10.925, P<0.001), attack history of cerebral infarction(OR=2.769, 95% CI: 1.237-6.197, P<0.05), age>70 years (OR= 2.549, 95% CI:1.633-3.980, P<0.001) and hyperglycemia (OR=1.808, 95% CI: 1.088-3.005, P<0.05) were independent prognostic factors for poor prognosis. Conclusion  Hyperglycemia was the independent prognostic factors for poor outcome in patients with acute stroke after six months of onset. Related Articles | Metrics

Select

Nursing of the patients of severe pancreatitis associated with diabetes mellitus in 64 cases Yuan Shunqiong 2014, 12 (4):  245-247.  doi: 10.3969/j.issn.1672-2302.2014.04.018 Abstract ( 1878 )   Objective To explore the nursing strategies for patients of severe pancreatitis associated with diabetes mellitus. Methods Holistic nursing was performed in the 64 patients of severe pancreatitis associated with diabetes mellitus between February and September of 2010, and the results were compared with control group(by conventional nursing) pertaining to blood glucose control, incidences of complications and scoring on the 36-Item Short Form Health Survey(SF-36)before and after treatment. Results The blood glucose level was downregulated significantly in the observational group with less time than the control group((t=3.65, 2.98, P<0.05). Still, the observational group had lower incidence of complications(6.25% vs. 25.00%, t=4.27, P<0.05), yet higher scoring on SF-36(t=3.62, 3.55, 4.62, 5.22, 4.01, 3.68, 3.94, 3.21, respectively, P<0.05). Conclusion Since severe acute pancreatitis may develop in quick manner, it is appropriate to give those patients with holistic nursing, which may improve the therapeutic outcomes and reduce the incidence of complications.   Related Articles | Metrics

Select

Meta-analysis on terbinafine and itraconazole for onychomycosis Li Xue1, An Qi2, Wang Qiufeng1, Yang Weiling1 2014, 12 (4):  248-251.  doi: 10.3969/j.issn.1672-2302.2014.04.019 Abstract ( 2655 )   Objective  To evaluate the efficacy and safety of terbinafine versus itraconazole for onychomycosis through meat-analysis. Methods  The studies involving randomized controlled trials (RCTs) were collected from the database, including Cochrane Library, Pubmed, CBMdisc, CNKI, VIP database and Wangfang database from the year of database creation to January 2014. After evaluation of the methodology on the studies included, the statistics was conducted using software RevMan5.2. Results  Eight RCTs were eligibly identified, which included 1 208 cases. Meta-analysis showed that terbinafine in the treatment of onychomycosis had led to higher cure rate  (OR=1.97; 95％CI: 1.27, 3.07, P＜0.01), yet the effective rate(OR=1.32；95％CI: 0.86, 2.03, P＞0.05) and adverse effects(OR=1.01； 95％CI: 0.76, 1.33, P＞0.05) remained no significance as compared with itraconazole. Conclusion  Terbinafine can be effective in treatment of onychomycosis. Related Articles | Metrics