Journal of Tropical Diseases and Parasitology

Journal of Tropical Diseases and Parasitology ›› 2014, Vol. 12 ›› Issue (4): 248-251.doi: 10.3969/j.issn.1672-2302.2014.04.019

Previous Articles     Next Articles

Meta-analysis on terbinafine and itraconazole for onychomycosis

Li Xue1, An Qi2, Wang Qiufeng1, Yang Weiling1   

  1. 1. Department of Dermatology, Second Artillery General Hospital of PLA , Beijing 100088, China.    2. Department of Urology, Second Artillery General Hospital of PLA Affiliated to Soochow University, Beijing 100088, China
  • Online:2014-12-10 Published:2015-01-27

Abstract:

Objective  To evaluate the efficacy and safety of terbinafine versus itraconazole for onychomycosis through meat-analysis. Methods  The studies involving randomized controlled trials (RCTs) were collected from the database, including Cochrane Library, Pubmed, CBMdisc, CNKI, VIP database and Wangfang database from the year of database creation to January 2014. After evaluation of the methodology on the studies included, the statistics was conducted using software RevMan5.2. Results  Eight RCTs were eligibly identified, which included 1 208 cases. Meta-analysis showed that terbinafine in the treatment of onychomycosis had led to higher cure rate  (OR=1.97; 95％CI: 1.27, 3.07, P＜0.01), yet the effective rate(OR=1.32；95％CI: 0.86, 2.03, P＞0.05) and adverse effects(OR=1.01； 95％CI: 0.76, 1.33, P＞0.05) remained no significance as compared with itraconazole. Conclusion  Terbinafine can be effective in treatment of onychomycosis.

Key words: Terbinafine, Itraconazole, Onychomycosis, Evidence based medicine, Meta-analysis