Abstract:

Objective To evaluate the efficacy and safety of rocephin versus rpectinomycin for uncomplicated gonorrhea by Meta- analysis . Methods The studies involving randomized controlled trials (RCTs) on ceftriaxone (rocephin) versus spectinomycin for uncomplicated gonorrhea were collected from the database, such as the Cochrane Library, Pubmed, CBMdisc, CNKI, VIP and Wanfang. After the necessary methodological quality evaluation of the selected studies, assessment of publication bias and sensitivity analysis, the statistic analysis was conducted by the software RevMan5.2. Results Six eligible reports were identified in this study,
including accumulative total 789 cases. The Meta-analysis results showed rocephin in the treatment of uncomplicated gonorrhea had higher effectiveness and recovery than the spectinomycin group（P<0.05）,which could increase the cure rate [OR1.18; 95%CI(1.06,3.34)，P<0.05] and the total effective rate [OR3.96; 95%CI(1.29,12.18), P<0.05]，but there were no significant difference among bacterial eradication rate and incidence of adverse reactions. Conclusion The ceftriaxone (rocephin) showed definite curative effect in the treatment of uncomplicated gonorrhea.