Abstract:

Objective To investigate the status of deep fungal infection in children, and analyze its sensitivity to first-line antibiotics for evidence to treat fungal infection. Methods The clinical data were retrospectively analyzed in 270 child inpatients with deep fungal infection undergone treatment in a hospital of Yanan area between March 2009 and December 2012. Antifungal susceptibility testing, including amphotericin B(AmB), fluconazole(FCZ), 5-flucytosine(5-FC) and itraconazole(ICZ) was performed in accordance with Clinical and Laboratory Standards Institute(CLSI) document M27-A2. Results The specimens obtained primarily using the nasopharyngeal swabs were isolated, and the results showed that Candida albicans was the highest(61.1%), followed by Candida glabrata,Candida tropicalis，Candida parapsilosis and Candida krusei. Drug sensitive test revealed that Candida albicans was highly sensitive to AmB and 5-FC. Conclusion Deep fungal infection is primarily associated with Candida, especially Candida albicans, and AmB and 5-FC have higher antifungal sensitivity. Surveillance shall be strengthened over the fungal infection and drug-resistance for reasonable use of antibiotics in clinic. 

Key words:  Pediatrics, Fungal infection, Antifungal susceptibility testing