热带病与寄生虫学

热带病与寄生虫学 ›› 2014, Vol. 12 ›› Issue (4): 209-211.doi: 10.3969/j.issn.1672-2302.2014.04.007

• 论著 • 上一篇    下一篇

干扰素α-2b与聚乙二醇干扰素α-2a治疗低病毒载量慢性丙型肝炎快速及早期病毒学应答临床观察

徐菁,欧亚非   

  1. 061001 河北沧州市， 沧州市传染病医院肝五科
  • 出版日期:2014-12-10 发布日期:2015-01-27

Interferon α-2b and pegylated interferon α-2a in therapy of chronic hepatitis C patients with low viral load: Clinical observation on the rapid and early virological

Xu Jing, Ou Yafei.   

  1. The Fifth Department of Cangzhou Hospital for Infectious Diseases, Cangzhou  061001, China
  • Online:2014-12-10 Published:2015-01-27

摘要： 目的  研究干扰素类型在低病毒载量慢性丙型肝炎抗病毒治疗应答的影响。 方法  选择120例慢性丙型肝炎患者为研究对象，将120例患者分为聚乙二醇干扰素α-2a（派罗欣，Peg-IFN）组58例和普通干扰素α2b（凯因益生）组62例。所有患者用干扰素联合利巴韦林抗病毒治疗。Peg-IFN组选用180μg每周注射1次，普通干扰素组为600 MU隔日注射1次。利巴韦林使用剂量900~1 200mg/d。疗程：达RVR之后再应用24周；达EVR之后再应用36周；对于12周未达EVR者再应用48周。对抗病毒治疗的应答情况与干扰素类型及丙肝病毒载量的关系进行回顾性分析。 结果  两组中，普通干扰素组RVR获得率为79％，EVR获得率为85.4％，派罗欣组的RVR获得率为81％，EVR获得率为89.6％。对于RVR的获得，χ2=0.009，P＞0.05，对于EVR的获得，χ2=0.036，P＞0.05，对于SVR的获得，χ2=0.010，P＞0.05，组间比较差异无统计学意义。 结论  在病毒载量较低的情况下，聚乙二醇干扰素α-2a与普通干扰素α-2b抗病毒治疗的RVR、EVR、SVR获得率差异无统计学意义。

关键词: 丙型肝炎, 聚乙二醇干扰素&alpha, -2a, 普通干扰素&alpha, -2b, 病毒学应答

Abstract:

 Objective  To observe the response of chronic hepatitis C patients with low viral load to antiviral treatment by different interferon(IFN) modality. Methods  120 patients with chronic hepatitis C were assigned to Peg-IFN group(n=58, treated with Peginterferon alfa-2a injection in dose of 180μg once a week) and recombinant human interferon α-2b injection group(n=62, administered in dose of 600 MU once every other day), and the two groups were given additional dosage of ribavirin by 900~1200 mg/d. The treatment course was as follows: 24 weeks were extended after rapid virological response(RVR), and 36 weeks after early virological response(EVR). For patients failed to meet EVR by the 12th week, 48 weeks were extended. The data were retrospectively analyzed on response to antiviral treatment, interferon modality and final viral load after treatment. Results  RVR and EVR were 79% and 85.4% for the patients treated with recombinant human interferon α-2b injection, and 81%, and 89.6 % for Peg-IFN group, respectively(χ2 = 0.009, P＞0.05; χ2 = 0.036, P＞0.05). There was no significance between groups regarding sustained virological response(SVR)(χ2 = 0.010, P＞0.05). Conclusion  Interferon α-2b and pegylated interferon α-2a may produce similar effects on chronic hepatitis C patients with lower viral load by statistical estimation of RVR, EVR and SVR.

Key words:  Chronic hepatitis C, Pegylated interferon α-2a, Recombinant human interferon α-2b, Virological response