热带病与寄生虫学

热带病与寄生虫学 ›› 2014, Vol. 12 ›› Issue (4): 248-251.doi: 10.3969/j.issn.1672-2302.2014.04.019

• 论著 • 上一篇    下一篇

特比萘芬与伊曲康唑治疗甲真菌病疗效的Meta分析

李雪,安琪#,王秋枫,杨维玲*   

  1. 100088  北京市，中国人民解放军第二炮兵总医院皮肤科（李雪、王秋枫、杨维玲），苏州大学附属中国人民解放军第二炮兵总医院泌尿外科（安琪）
  • 出版日期:2014-12-10 发布日期:2015-01-27

Meta-analysis on terbinafine and itraconazole for onychomycosis

Li Xue1, An Qi2, Wang Qiufeng1, Yang Weiling1   

  1. 1. Department of Dermatology, Second Artillery General Hospital of PLA , Beijing 100088, China.    2. Department of Urology, Second Artillery General Hospital of PLA Affiliated to Soochow University, Beijing 100088, China
  • Online:2014-12-10 Published:2015-01-27

被引次数

7

摘要： 目的  利用Meta分析评价特比萘芬与伊曲康唑治疗甲真菌病的疗效。 方法  检索Cochrane图书馆、Pubmed数据库、中国生物医学文献数据库、CNKI数据库、VIP数据库、万方数据库等，纳入特比萘芬与伊曲康唑对比治疗甲真菌病的随机对照试验（RCT），进行方法学质量评价，并采用RevMan5.2软件进行统计分析。 结果  8篇RCT文献纳入本项研究，累计病例1 208例。Meta分析结果显示，特比萘芬对提高痊愈率[OR1.97；95％CI（1.27，3.07），P＜0.01]具有明显差异，而在有效率[OR 1.32；95％CI（0.86，2.03），P＞0.05]和不良反应[OR 1.01；95％CI（0.76，1.33），P＞0.05]方面则无明显差异。 结论   特比萘芬在治疗甲真菌病中疗效确切，是治疗甲真菌病的有效方法。

关键词: 特比萘芬, 伊曲康唑, 甲真菌病, 循证医学, Meta分析

Abstract:

Objective  To evaluate the efficacy and safety of terbinafine versus itraconazole for onychomycosis through meat-analysis. Methods  The studies involving randomized controlled trials (RCTs) were collected from the database, including Cochrane Library, Pubmed, CBMdisc, CNKI, VIP database and Wangfang database from the year of database creation to January 2014. After evaluation of the methodology on the studies included, the statistics was conducted using software RevMan5.2. Results  Eight RCTs were eligibly identified, which included 1 208 cases. Meta-analysis showed that terbinafine in the treatment of onychomycosis had led to higher cure rate  (OR=1.97; 95％CI: 1.27, 3.07, P＜0.01), yet the effective rate(OR=1.32；95％CI: 0.86, 2.03, P＞0.05) and adverse effects(OR=1.01； 95％CI: 0.76, 1.33, P＞0.05) remained no significance as compared with itraconazole. Conclusion  Terbinafine can be effective in treatment of onychomycosis.

Key words: Terbinafine, Itraconazole, Onychomycosis, Evidence based medicine, Meta-analysis