热带病与寄生虫学

热带病与寄生虫学 ›› 2014, Vol. 12 ›› Issue (4): 202-203,211.doi: 10.3969/j.issn.1672-2302.2014.04.005

• 论著 • 上一篇    下一篇

儿科患者深部真菌感染的调查研究

张欠欠,成俊珍   

  1. 716000 陕西延安，延安大学医学院（张欠欠），延安大学附属医院（成俊珍）
  • 出版日期:2014-12-10 发布日期:2015-01-27
  • 基金资助:

    延安大学青年专项基金资助项目（YDQ2013-03）

Investigation on the deep fungal infection in children

Zhang Qianqian1,Cheng Junzhen2   

  1. 1.The Medical College of Yan′an University,Yan′an 716000,China.  2.Yan'an University Affiliated Hospital.
  • Online:2014-12-10 Published:2015-01-27

被引次数

1

摘要： 目的 探讨儿童深部真菌感染情况，分析其对常用抗真菌药物的敏感性，为真菌感染的治疗和预防提供依据。方法 回顾性分析了2009年3月~2012年12月延安市某医院270例确诊为深部真菌感染住院患儿的临床资料，药敏试验严格按照2006年CLSI M272A2规则及标准进行AmB、FCZ、5－FC、ICZ 4种抗真菌药敏检测。 结果 真菌感染标本主要来源于咽拭子，白假丝酵母菌的分离率最高(61.1%)，其次为光滑假丝酵母菌、热带假丝酵母菌、近平滑假丝酵母菌和克柔假丝酵母菌。药敏实验结果表明，假丝酵母菌对AmB、5－FC的敏感性较高。 结论 儿科患者中分离的真菌中以假丝酵母菌属最多,并以白假丝酵母菌为主；AmB、5－FC均有较高的抗真菌活性。应加强对临床真菌感染与耐药性情况的监测,以指导临床合理使用抗生素。

关键词:  , 儿科, 真菌感染, 药敏试验

Abstract:

Objective To investigate the status of deep fungal infection in children, and analyze its sensitivity to first-line antibiotics for evidence to treat fungal infection. Methods The clinical data were retrospectively analyzed in 270 child inpatients with deep fungal infection undergone treatment in a hospital of Yanan area between March 2009 and December 2012. Antifungal susceptibility testing, including amphotericin B(AmB), fluconazole(FCZ), 5-flucytosine(5-FC) and itraconazole(ICZ) was performed in accordance with Clinical and Laboratory Standards Institute(CLSI) document M27-A2. Results The specimens obtained primarily using the nasopharyngeal swabs were isolated, and the results showed that Candida albicans was the highest(61.1%), followed by Candida glabrata,Candida tropicalis，Candida parapsilosis and Candida krusei. Drug sensitive test revealed that Candida albicans was highly sensitive to AmB and 5-FC. Conclusion Deep fungal infection is primarily associated with Candida, especially Candida albicans, and AmB and 5-FC have higher antifungal sensitivity. Surveillance shall be strengthened over the fungal infection and drug-resistance for reasonable use of antibiotics in clinic. 

Key words:  Pediatrics, Fungal infection, Antifungal susceptibility testing