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Mechanisms of macrophage polarization and its role in common diseases WANG Yong-kang, LI Jia-yi, GUAN Fei, LEI Jia-hui Journal of Tropical Diseases and Parasitology    2022, 20 (2): 103-108,112.   Abstract （4264）      PDF （1747KB）（18679）       Knowledge map    Macrophages are important components in human innate immune system. They are highly plastic and can differentiate into pro-inflammatory M1 and anti-inflammatory M2 under the stimulation of different microenvironmental signals. Polarization of macrophages is regulated by many signaling pathways and transcription factors, and M1/M2 phenotype are involved in the occurrence and development of a variety of diseases, such as tumor, type Ⅱ diabetes and severe acute pancreatitis, etc. In this paper, we reviewed the main signaling pathways related to macrophage polarization and its polarization state in common disorders, and described the importance of balance of macrophage polarization in maintaining homeostasis, with an attempt to provide new ideas for related clinical research.  Related Articles | Metrics

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Role of ATP-P2X7R axis in inflammatory diseases YAN Shi-yi, CHEN Shi-yao, GUAN Fei, LEI Jia-hui Journal of Tropical Diseases and Parasitology    2022, 20 (1): 50-56,60.   Abstract （2336）      PDF （1170KB）（16617）       Knowledge map    In addition to being an energy source, adenosine triphosphate (ATP) can also bind to purinergic receptor 2X7 (P2X7R) on the cell surface to activate downstream related signaling pathways and initiate various pathophysiological reactions. P2X7R is widely expressed on many immune cells, such as macrophages, monocytes, lymphocytes and eosinophils, etc. ATP-mediated P2X7R pathways can play important roles in inflammatory diseases. This paper reviewed the basic concepts, discovery history, main sources and physiological and pathological functions of related molecules involved in P2X7R, and the role of ATP-P2X7R signaling pathway in inflammatory diseases of digestive system, respiratory system, nervous system and immune system. Related Articles | Metrics

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Role of UGTs in liver diseases and its transcriptional regulation mechanism XUE Qing-kai, HUANG Yu-zheng Journal of Tropical Diseases and Parasitology    2022, 20 (1): 36-42.   Abstract （2947）      PDF （957KB）（15323）       Knowledge map    UDP-glucuronosyltransferases (UGTs), an important phase Ⅱ metabolic enzyme and highly expressed in the liver, plays pivotal role in the metabolism and clearance of substances. Therefore, transcriptional regulation of UGTs is critical for the occurrence and development of liver diseases. This paper aims at reviewing the general families of UGT and their relationship with metabolism, and investigating the expression and transcriptional regulation of UGTs in liver disease, as well as the study of UGTs in disease mechanism and implications of UGTs in clinical treatment of liver disease.  Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2015, 13 (3): 182-186.   DOI: 10.3969/j.issn.1672-2302.2015.03.019 Abstract （2987）      PDF （459KB）（13889）       Knowledge map    Related Articles | Metrics

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Research progress on human Demodex mites and demodicidosis in China ZHAO Ya-e Journal of Tropical Diseases and Parasitology    2022, 20 (3): 158-164.   Abstract （2071）      PDF （993KB）（12636）       Knowledge map    Since Demodex was discovered in 1842 by Simon, human beings have experienced a long process of understanding the pathogenicity of Demodex, particularly, the contribution to the identification as well as prevention and control of demodicidosis by Chinese scholars can't be ignored. In this paper, the research progress in pathogenicity confirmation and pathogenic mechanism, diagnosis and detection, prevalence and control, as well as that at the molecular level of Demodex in China were reviewed, aiming at promoting the development of demodicosis prevention and control in greater extent, in order to reduce the harm of demodicosis to Chinese people, and improve the life quality and happiness index of our population. Related Articles | Metrics

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Epidemic status and prevention and control progress of cryptosporidiosis in China WANG Xu, SHEN Yu-juan, CAO Jian-ping Journal of Tropical Diseases and Parasitology    2022, 20 (3): 136-148.   Abstract （2822）      PDF （1049KB）（12268）       Knowledge map    Protozoa of Cryptosporidium spp. can be transmitted through the activities of humans and animals, causing human cryptosporidiosis, which was considered as one of the six most important pathogens of diarrhea in the world. It is a great threat to children and immunocompromised people, and may cause outbreak of public health events. However, there are no effective drugs or vaccines for the treatment and prevention of this infection at present. Therefore, the prevention and control of cryptosporidiosis is extremely difficult, and has attracted more and more attention around the world. In this paper, we summarized the situation of cryptosporidium infection in human over 30 years since the first case of cryptosporidiosis was reported in China in 1987, discussed the risk factors of Cryptosporidium transmission such as water and food contamination, infection of domestic animals, and seasonal epidemic situation, and introduced the progress, challenges and strategies of cryptosporidiosis control in China. Based on the existing survey and research results, Cryptosporidium spp. that can infect humans are widely distributed in China, and patients of HIV/AIDS or malignant tumor and drug addicts are susceptible population that call for attention. The main pathogenic species include C. hominis and C. parvum.. Considering the risk factors and prevention and control status of cryptosporidiosis, comprehensive prevention and control strategies should be implemented in terms of monitoring networks, prevention and control measures, technologies, water purification and health education, and the "One Health" public health concept should be practiced in all links of "parasites-humans- reservoir host-environment", so as to achieve effective monitoring and control of cryptosporidiosis in China.  Related Articles | Metrics

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Epidemic status and research progress of babesiosis in China CHEN Mu-xin, XUE Jing-bo, AI Lin, et al Journal of Tropical Diseases and Parasitology    2022, 20 (3): 149-157.   Abstract （2309）      PDF （1301KB）（12107）       Knowledge map    Babesiosis is a zoonotic parasitic disease caused by Babesia infection. Babesia is transmitted through tick bites, blood transfusion or organ transplantation, and primarily parasitizes intracellularly in the erythrocytes of humans or other vertebrates. Babesia infecting humans mainly comprises Babesia microti, B. venatorum, B. duncani, B. divergens, etc. Babesiosis distributed worldwidely. This disease occurs more frequently in summer and autumn, yet is a new and rare parasitic disease in China, therefore many patients failed to receive timely treatment due to unavailable sensitive and effective methods for diagnosis of basesiosis in clinic in the past. However, with highly sensitive molecular biology detection techniques being clinically introduced, more cases of babesiosis were identified and reported. This paper reviewed the case reports of human babesiosis in China since 1943, summarized the research progress in diagnosis, treatment and pathogenesis of babesiosis, and analyzed the challenges and prospects for the prevention and control of babesiosis in China. Related Articles | Metrics

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Human parasitic diseases and uncommon or rare parasitic diseases in China WU Zhong-dao Journal of Tropical Diseases and Parasitology    2022, 20 (3): 121-125.   Abstract （2163）      PDF （884KB）（11146）       Knowledge map    China is a country with parasitic diseases being widespread, some of which seriously bring harm to people's health and hinder economic and social development. Since the founding of the People's Republic of China, the Party and the state have attached great importance to the prevention and control of parasitic diseases, and remarkable achievements have been made in the prevention and control of parasitic diseases in China. However, with the increase of international exchanges, the change of ecological environment and the transformation of production and life style, uncommon or rare parasitic diseases occur frequently, which should be deserved great attention. In this paper, the types and classification of parasitic diseases in China were introduced, and the prevalence, prevention and control of common parasitic diseases in China were summarized. The concepts, types and diagnoses of uncommon or rare parasitic diseases were discussed in order to provide reference for colleagues in this field. Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2017, 15 (3): 149-.   Abstract （1025）      PDF （644KB）（10306）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2015, 13 (2): 120-124.   DOI: 10.3969/j.issn.1672-2302.2015.02.022 Abstract （2525）      PDF （492KB）（9959）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2016, 14 (4): 245-250.   DOI: 10.3969/j.issn.1672-2302.2016.04.021 Abstract （1975）      PDF （465KB）（9684）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2015, 13 (1): 59-61.   DOI: 10.3969/j.issn.1672-2302.2015.01.018 Abstract （3018）      PDF （418KB）（9419）       Knowledge map    Related Articles | Metrics

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Interpretation and consideration of 2020 Edition Technical Specifications for TB Prevention and Control in China YAO Song, FANG Xue-hui Journal of Tropical Diseases and Parasitology    2020, 18 (3): 138-141,137.   Abstract （2456）      PDF （1290KB）（8664）       Knowledge map    In order to help the tuberculosis(TB) prevention and control professionals at each level better understand and implement the Technical Specifications for TB Prevention and Control in China (2020 Edition), we attempt to make an interpretation on this new specifications and comparison with the changes between 2008 Technical Specifications and the Guidelines for the Implementation of TB Control Programs in China. The paper focuses on the interpretation and consideration of the new specifications pertinent to prevention and control strategies, enhancement of prevention, prevention and control of key population, service system provision, screening of the patients, together with their diagnosis, treatment and management,etc. , with an expectation to provide specific guides to the professionals in TB prevention and control at each level in their work practice. Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2019, 17 (3): 174-175,180.   Abstract （2294）      PDF （1177KB）（8514）       Knowledge map    Related Articles | Metrics

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Research progress of tea tree oil in the treatment of eye diseases caused by Demodex ZHENG Xin-wu, XIE Si-jian, XIE Wen-jun Journal of Tropical Diseases and Parasitology    2023, 21 (1): 57-61.   DOI: 10.3969/j.issn.1672-2302.2023.01.011 Abstract （2293）   HTML （28）    PDF （838KB）（8149）       Knowledge map    Ocular Demodex infection can cause discomfort of the ocular surface and a variety of ocular conditions, and the incidence has been increasing in recent years. Tea tree oil and its derivatives not only have significant acaricidal effect, but also have antibacterial and anti-inflammatory activities, and are commonly used in the treatment of Demodex eye disease. Currently, various kinds of preparations from tea tree oil are available, yet the safety and optimal use of the related extract have not been fully clarified. This paper reviewed the mechanism, application, safety and efficacy of tea tree oil in the treatment of Demodex eye conditions, with an attempt to provide reference for clinical use of this extract for ocular Demodex infestation. Reference | Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2015, 13 (1): 53-58.   DOI: 10.3969/j.issn.1672-2302.2015.01.017 Abstract （2886）      PDF （539KB）（7175）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2019, 17 (3): 176-180.   Abstract （1485）      PDF （646KB）（7126）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2017, 15 (1): 60-62,57.   DOI: 10.3969/j.issn.1672-2302.2017.01.019 Abstract （1983）      PDF （489KB）（6840）       Knowledge map    Related Articles | Metrics

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Journal of Tropical Diseases and Parasitology    2017, 15 (4): 244-247.   Abstract （1818）      PDF （788KB）（6563）       Knowledge map    Related Articles | Metrics

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Role and mechanism of melatonin in the treatment of infectious diseases GAO Yang, GUAN Fei, LEI Jiahui Journal of Tropical Diseases and Parasitology    2024, 22 (5): 315-320.   DOI: 10.20199/j.issn.1672-2302.2024.05.012 Abstract （1396）   HTML （2）    PDF （935KB）（6128）       Knowledge map    Melatonin (MT) is an endogenous hormone that acts as a safe and effective sleep aid for regulating the circadian cycle. In addition to its traditional functions, more researches suggest that MT can play an important role in the treatment of infectious diseases. The therapeutic mechanism of MT in infectious diseases mainly involves the effect of reducing tissue damage caused by infection via regulating oxidative stress and enhancing immune function induced by regulating circadian rhythm to recruit immune cells. Moreover, MT can exert an anti-inflammatory effect by regulating Th1/Th2 development and differentiation, NF-κB phosphorylation and so on, and affect the apoptosis pathway to play a certain anti-infective effect. Based on the above functions of MT, this article summarizes the research status and mechanism of MT in the treatment of infectious diseases in order to provide a theoretical basis for the application of MT against infection in clinical settings. Reference | Related Articles | Metrics