热带病与寄生虫学

热带病与寄生虫学 ›› 2022, Vol. 20 ›› Issue (3): 149-157.

• 创刊50周年特约专稿 • 上一篇    下一篇

我国巴贝虫病流行现状与研究进展

陈木新1,2,3，薛靖波1，艾琳1，宋鹏1,3，蔡玉春1，陈家旭1,3   

  1. 1. 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，国家级热带病国际联合研究中心，上海 200025；
    2. 深圳市疾病预防控制中心； 3. 海南热带病研究中心（国家热带病研究中心海南分中心）
  • 收稿日期:2022-05-22 出版日期:2022-06-20 发布日期:2022-06-30
  • 通信作者: 陈家旭，E-mail：chenjx@nipd.chinacdc.cn
  • 作者简介:陈木新，男，博士，研究员，研究方向：媒传热带病控制。E-mail：chenmx@nipd.chinacdc.cn； 薛靖波，男，硕士，助理研究员，研究方向：空间流行病学。E-mail：xuejb@nipd.chinacdc.cn 陈木新、薛靖波同为第一作者
  • 基金资助:
    上海市第五轮公共卫生体系建设三年行动计划重点学科项目（GWV-10.1-XK13）；国家重点研发计划项目(2021YFC2300800、2021YFC2300803)；上海市自然科学基金项目（18ZR1443500）；深圳市科技创新委员会面上项目（JCYJ20210324135207021）

Epidemic status and research progress of babesiosis in China

CHEN Mu-xin1,2,3, XUE Jing-bo1, AI Lin1, SONG Peng1,3, CAI Yu-Chun1, CHEN Jia-xu1,3   

  1. 1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China
    2. Shenzhen Center for Disease Control and Prevention; 
    3. Hainan Center for Tropical Diseases Research (Hainan Branch of Chinese Center for Tropical Diseases Research)
  • Received:2022-05-22 Online:2022-06-20 Published:2022-06-30

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摘要： 巴贝虫病是由巴贝虫感染引起的一类人兽共患寄生虫病。巴贝虫经蜱叮咬、输血或器官移植等途径传播，主要寄生于人或其他脊椎动物红细胞内。感染人体的巴贝虫主要有田鼠巴贝虫、猎户巴贝虫、邓肯巴贝虫、分歧巴贝虫等。巴贝虫病呈世界性分布，多发于夏秋季节，在我国属于新发、罕见寄生虫病。过去临床上缺乏敏感有效的诊断方法，导致很多巴贝虫病患者未能得到及时治疗。随着高敏感性的分子生物学检测技术在临床上的应用，巴贝虫病病例报告数量逐渐增多。本文详细回顾了1943年至今我国人巴贝虫病病例报告情况，概述了巴贝虫病诊断、治疗和致病机制等方面的研究进展，分析了我国巴贝虫病防控的挑战和前景。

关键词: 巴贝虫病, 流行, 临床表现, 诊断, 治疗, 研究进展, 挑战

Abstract: Babesiosis is a zoonotic parasitic disease caused by Babesia infection. Babesia is transmitted through tick bites, blood transfusion or organ transplantation, and primarily parasitizes intracellularly in the erythrocytes of humans or other vertebrates. Babesia infecting humans mainly comprises Babesia microti, B. venatorum, B. duncani, B. divergens, etc. Babesiosis distributed worldwidely. This disease occurs more frequently in summer and autumn, yet is a new and rare parasitic disease in China, therefore many patients failed to receive timely treatment due to unavailable sensitive and effective methods for diagnosis of basesiosis in clinic in the past. However, with highly sensitive molecular biology detection techniques being clinically introduced, more cases of babesiosis were identified and reported. This paper reviewed the case reports of human babesiosis in China since 1943, summarized the research progress in diagnosis, treatment and pathogenesis of babesiosis, and analyzed the challenges and prospects for the prevention and control of babesiosis in China.

Key words: Babesiosis, Epidemic, Clinical manifestations, Diagnosis, Treatment, Research progress, Challenges

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