热带病与寄生虫学

热带病与寄生虫学 ›› 2020, Vol. 18 ›› Issue (1): 59-63.

• 综述 • 上一篇    

寄生虫的抗肿瘤效应及其免疫机制

傅昌芳1 , 储宣宁2 , 操治国3∗   

  1. 1. 中国科学技术大学附属第一医院(安徽省立医院),合肥 230001; 2. 中国药科大学生命科学与技术学院; 3. 安徽省 寄生虫病防治研究所
  • 收稿日期:2020-01-17 出版日期:2020-03-10 发布日期:2020-03-10
  • 通信作者: ∗通讯作者,操治国,E-mail:ahzhiguo@126.com
  • 作者简介:傅昌芳,女,硕士,副主任药师,研究方向:肿瘤药学。 E-mail:ahslyyfcf@sina.com
  • 基金资助:
    安徽省教育厅2017年高等学校省级质量工程项目(2017jyxm1100)

Anti-tumor immune effect and mechanism induced by parasites

FU Chang-fang1 , CHU Xuan-ning2 , CAO Zhi-guo3∗   

  1. 1. The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China; 2. School of Life Sciences and Technology, China Pharmaceutical University; 3. Anhui Provincial Institute of Parasitic Diseases
  • Received:2020-01-17 Online:2020-03-10 Published:2020-03-10
  • Contact: ∗ Corresponding author, E-mail:ahzhiguo@126.com

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摘要： 本文阐述了寄生虫感染和寄生虫抗原诱导的抗肿瘤效应以及几种常见寄生虫诱导的抗肿瘤相关 免疫机制。 宿主感染某些寄生虫后,免疫系统功能得到增强,从而抑制肿瘤细胞的生长、转移和肿瘤血管的生成,且 这一理论机制已在多种动物模型中得到证实。 但寄生虫感染在临床上抗肿瘤效果如何,以及寄生虫相关抗原应用 于人体后是否存在潜在风险,这些问题值得进一步研究。

关键词: 寄生虫, 感染, 抗原, 抗肿瘤, 免疫机制

Abstract: This paper describes the anti-tumor effect from parasite infection and the anti-tumor immune mechanism induced by several common parasites. The findings showed that when a host was infected with certain parasite, the cellular immunity would be enhanced, resulting in inhibited growth of the tumor cells, metastasis and tumor angiogenesis, and this mechanism was theoretically confirmed in several animal models. However, certain aspects, including the anti-tumor effect of parasite infection in clinic and whether there should be potential risks in humans following use of parasite-derived antigens, need further investigation.

Key words: Parasite, Infection, Antigen, Anti-tumor, Immune mechanism

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