热带病与寄生虫学

热带病与寄生虫学 ›› 2024, Vol. 22 ›› Issue (1): 42-46.doi: 10.3969/j.issn.1672-2302.2024.01.009

• 临床研究 • 上一篇    下一篇

皖南地区8 199例婴幼儿TORCH感染血清学检测结果分析

蒋路晴(), 李磊, 徐梓琛, 翟蓥, 庄玲丹, 付夏, 方芳, 王玉萍, 武其文()   

  1. 皖南医学院第一附属医院，安徽 芜湖 241001
  • 收稿日期:2023-08-30 出版日期:2024-02-20 发布日期:2024-03-15
  • 通信作者: 武其文, E-mail: yjslab@163.com
  • 作者简介:蒋路晴，女，硕士在读，研究方向：临床检验诊断学。E-mail: 20229174@stu.wnmc.edu.cn
  • 基金资助:
    安徽省高校自然科学研究重点项目(2022AH051221);生物活性大分子研究安徽省重点实验室开放课题项目(LAB202204)

Analysis of the serological test results in 8 199 infants with TORCH infection in southern Anhui Province

JIANG Luqing(), LI Lei, XU Zichen, ZHAI Ying, ZHUANG Lingdan, FU Xia, FANG Fang, WANG Yuping, WU Qiwen()   

  1. The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China
  • Received:2023-08-30 Online:2024-02-20 Published:2024-03-15
  • Contact: WU Qiwen, E-mail: yjslab@163.com

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摘要：

目的 探讨皖南地区近年来TORCH病原体，即弓形虫（Toxoplasma gondii, TOX）、风疹病毒（rubella virus, RV）、巨细胞病毒（cytomegalovirus, CMV）和单纯疱疹病毒（herpes simplex virus, HSV）在婴幼儿人群的感染状况及流行特点，为儿童相关疾病的预防、诊断和治疗提供参考。方法 回顾性分析2016年4月—2023年3月皖南医学院第一附属医院接诊的0~3岁婴幼儿TORCH感染血清IgM和IgG抗体检测结果，并对不同年龄、年份的TORCH阳性率进行比较分析。结果 共有8 199例0~3岁婴幼儿进行TORCH感染血清学筛查检测，其中男性4 631例，女性3 568例。婴幼儿TOX、RV、CMV、HSV Ⅰ和HSV Ⅱ的IgM抗体阳性率分别为0.11%、0.20%、0.89%、0和0，差异有统计学意义（χ2=100.000，P<0.05）；相对应的IgG抗体阳性率分别为10.81%、78.36%、98.32%、82.38%和13.45%，差异有统计学意义（χ2=22 828.211，P<0.05）。不同年龄组比较，婴儿组CMV-IgM阳性率（11.90%）高于新生儿组（0.20%）和幼儿组（1.40%），差异均有统计学意义（χ2=672.920、20.569，P均<0.017）；新生儿组TOX-IgG、RV-IgG、CMV-IgG、HSV Ⅰ-IgG和HSV Ⅱ-IgG阳性率（11.01%、79.88%、98.76%、85.35%、13.72%）高于婴儿组（6.71%、49.35%、96.54%、50.87%、9.74%），差异均有统计学意义（χ2=8.369、237.184、16.033、373.121、5.902，P均<0.017）。不同年份比较，CMV-IgM阳性率2016年最高，各年差异有统计学意义（χ2=15.816，P<0.05）；不同年份TOX-IgG、RV-IgG、CMV-IgG、HSV Ⅰ-IgG、HSV Ⅱ-IgG阳性率差异均有统计学意义（χ2=216.002、90.545、37.047、59.527、57.623，P均<0.05）。结论 皖南地区0~3岁婴幼儿中TORCH既往感染以CMV、HSV Ⅰ和RV为主，现症感染主要为CMV，对婴幼儿进行TORCH感染筛查检测对于保护儿童的健康至关重要。此外，应做好妊娠规划、产前保健和筛查，预防TORCH感染。

关键词: TORCH感染, 婴幼儿, 抗体检测, 皖南地区

Abstract:

Objective To investigate the infection status and epidemiological characteristics of TORCH (Toxoplasma gondii, TOX; rubella virus, RV; cytomegalovirus, CMV; herpes simplex virus, HSV) infection in the infants in southern Anhui area in recent years for references for prevention, diagnosis and treatment of related infections in children. Methods The results of serum IgM and IgG antibody tests for TORCH infection in infants aged 0 to 3 years old diagnosed in the First Affiliated Hospital of Wannan Medical College between April 2016 and March 2023 were reviewed, and the positive rates of TORCH infection in different ages and years were also comparatively analyzed. Results A total of 8 199 infants (4 631 males and 3 568 females) aged 0 to 3 years underwent serological tests for screening TORCH infection. The positive rate of IgM in the infants was 0.11%, 0.20%, 0.89%, 0 and 0, respectively, for TOX, RV, CMV, HSV Ⅰ and HSV Ⅱ. The difference was significant (χ2=100.000, P<0.05). The corresponding positive rate of IgG was 10.81%, 78.36%, 98.32%, 82.38% and 13.45%, respectively (χ2=22 828.211, P<0.05). Comparing different age groups, the positive rate of CMV-IgM was higher in infant group (11.90%) than that in newborn group (0.20%) and young children group (1.40%), with statistical difference (χ2=672.920, 20.569, both P<0.017). The positive rates of TOX-IgG, RV-IgG, CMV-IgG, HSV Ⅰ-IgG, and HSV Ⅱ-IgG were higher in newborn group (11.01%, 79.88%, 98.76%, 85.35%, 13.72%) than those in infant group (6.71%, 49.35%, 96.54%, 50.87%, 9.74%) (χ2=8.369, 237.184, 16.033, 373.121, 5.902, respectively, all P<0.017). Comparison of the differences among years showed that the positive rate of CMV-IgM was the highest in 2016 (χ2=15.816, P<0.05). The positive rates of TOX-IgG, RV-IgG, CMV-IgG, HSV Ⅰ-IgG and HSV Ⅱ-IgG were significantly different among years (χ2=216.002, 90.545, 37.047, 59.527, 57.623, respectively, all P<0.05). Conclusion Previous TORCH infection in infants aged 0 to 3 years in southern Anhui Province was mainly caused by CMV, HSV Ⅰ, and RV, and current infection is dominated by CMV. Screening for TORCH infection in infants is very important to protect children's health. In addition, reasonable pregnancy planning, prenatal health care and screening in pregnant women are essential to prevent TORCH infection.

Key words: TORCH infections, Infant, Antibody detection, Southern Anhui area

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