Objective　To analyze the surveillance data of soil-transmitted nematode disease in Hefei City from 2016 to 2020 for scientific evidence to develop prevention and control measures for this infection during the 14th five-years in Hefei.Methods　Surveillance sites for soil-transmitted nematodes were selected in Feidong City,Lujiang County,Chaohu City, Feixi County and Changfeng County between 2016 to 2020 and zoned into 5 areas according to the geographical location east,west,south,north and middle areas . Then one administrative village was selected from a township to serve as the surveillance site. No less than 200 permanent residents aged 3 years or above were annually included by cluster sampling method from each administrative village for fecal examination using the modified Kato -Katz thick smear method to investigate the infection rate of soil-transmitted nematodes.Results　Totally,9 339 residents underwent the tests. The total infection rate was 0. 46%(43/9 339),without mixed infection. The infection rate 0. 02%(2/9 339),0. 03%(3/9 339),0. 33%(31/9 339) and 0. 07%(7/9 339),respectively for roundworm,whipworm,hookworm and pinworm,and the number of hookworm infection was the largest. The infections were the highest in Feixi County(0. 95%),and different from Chaohu City(0. 16%) and Feidong County(0. 24%)(χ 2 =13. 287,7. 275;both P<0. 05). The infection rate in females and males was 0. 45%(21/4 674) and 0. 47%(22/4 665),respectively,without significant difference. Pinworm infection was primarily seen in population aged below 10 years. Hookworm infection was most seen in those aged over 50(0. 46%) and different from those aged under 50 years(0. 19%)(χ 2 =5. 122,P<0. 05).Conclusion　The infection rate of soil-transmitted nematodes remains at a lower level in the population in Hefei City between 2016 and 2020. Hookworm infection was the most in people aged over 50 years,which suggests that this population group should be target in following surveillance in hookworm infection.