热带病与寄生虫学

热带病与寄生虫学 ›› 2022, Vol. 20 ›› Issue (6): 310-312,316.

• 防治研究 • 上一篇    下一篇

2016—2020年武汉市晚期血吸虫病死亡患者调查分析

张佳京，徐明星，罗华堂，王浩，李洋，熊月琳，王帅，刘毅俊   

  1. 武汉市疾病预防控制中心，湖北 武汉 430020
  • 收稿日期:2022-08-03 出版日期:2022-12-20 发布日期:2023-01-19
  • 作者简介:张佳京，男，本科，医师，研究方向：血吸虫病防治。E-mail：396110972@qq.com
  • 基金资助:
    武汉市卫生健康科研项目（WG20C01）

Investigation and analysis on the death of advanced schistosomiasis in Wuhan City from 2016 to 2020

ZHANG Jia-jing, XU Ming-xing, LUO Hua-tang, WANG Hao, LI Yang, XIONG Yue-lin, WANG Shuai, LIU Yi-jun   

  1. Wuhan Center for Disease Control and Prevention, Wuhan 430020, Hubei Province, China
  • Received:2022-08-03 Online:2022-12-20 Published:2023-01-19

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摘要： 摘要：目的  分析和掌握武汉市晚期血吸虫病（简称晚血）死亡患者的流行病学特征和死因，为改善晚血患者生命质量采取针对性措施提供参考依据。方法  收集整理和分析2016—2020年武汉市晚血死亡患者基本情况、诊断、治疗和死亡原因。结果  2016—2020年武汉市晚血死亡患者共168人，其中男性94人，女性74人；临床诊断病例147人，确诊病例21人；腹水型127人，其他类型41人，包含巨脾型39人和结肠增殖型2人。平均诊断年龄为（61.25±11.94）岁，平均死亡年龄（70.56±10.21）岁，有164人经过至少1次治疗。死因主要为消化系统疾病（128人），其中肝硬化68人、腹水21人、肝癌16人、消化道出血14人、其他消化系统肿瘤9人；其他死因40人，其中心脑血管疾病19人、呼吸系统疾病2人、其他肿瘤4人和其他情况15人。不同诊断类型的病程时间差异有统计学意义（Z=-3.06，P<0.05），不同临床分型的诊断年龄、死亡年龄和病程时间的差异有统计学意义（t=-5.33、5.11，Z=-3.97，P均<0.05），不同死因的病程时间差异有统计学意义（Z=-2.46，P<0.05），患者病程时间与诊断年龄存在关联，诊断越早的患者的病程时间越长（r=-0.463，P<0.05）。结论  晚血患者平均死亡年龄有所提高，晚期并发症依然是患者的主要健康危害和死亡原因，应继续坚持晚血免费救治措施，重视晚血的早发现、早诊断和早治疗，提高晚血患者生存质量。

关键词: 晚期血吸虫病, 死亡原因, 流行病学, 武汉市

Abstract: Abstract: Objective   To understanded the epidemiological characteristics and causes of the death of advanced schistosomiasis in Wuhan City for evidence to plan targeted measures to improve the quality of life of such patients. Methods   The data associated with the general demographic information, diagnosis, treatment and cause of death was collected and analyzed in the death of advanced schistosomiasis in Wuhan area from 2016 to 2020. Results In total, 168 deaths (94 males, 74 females) of advanced schistosomiasis were reported from 2016 to 2020 in Wuhan. There were 147 clinical diagnosed cases and 21 confirmed cases. 127 cases were associated with ascites, 41 with other types, including 39 with splenomegaly and 2 with colon thickening. The mean age at diagnosis was (61.25±11.94) years, and the mean age at death was (70.56±10.21) years. 164 patients had at least one treatment. The causes of death were involved in 128 cases died of digestive system disorders, including liver cirrhosis in 68, ascites in 21, liver cancer in 16, gastrointestinal bleeding in 14 and other digestive system tumors in 9; other causes of death were 40, including cardiovascular and cerebrovascular disease in 19, respiratory diseases in 2, other tumors in 4 and other conditions in 15. The difference was significant in disease duration among different types of diagnosed condition (Z=-3.06, P<0.05), in the age at diagnosis, the age at death and the disease duration among different clinical classifications (t=-5.33, t=5.11; Z=-3.97, all P<0.05) as well as in the disease duration and different causes of death (Z=-2.46, P<0.05). The disease duration was correlated with the age at diagnosis, patients with an earlier age at diagnosis had a longer disease duration (r=-0.463, P<0.05). Conclusion The lifetime of patients with advanced schistosomiasis in Wuhan City has been improved, yet advanced schistosomiasis complications are still the major health hazard and cause of death for such patients. The findings suggest that the policy of free lifesaving should be continuously adhered, and more attention to early detection, early diagnosis and early treatment should be paid for improving the quality of life of patients with advanced schistosomiasis.

Key words: Advanced schistosomiasis, Cause of death, Epidemiology, Wuhan City

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