热带病与寄生虫学

热带病与寄生虫学 ›› 2016, Vol. 14 ›› Issue (4): 225-227,218.doi: 10.3969/j.issn.1672-2302.2016.04.013

• 论著 • 上一篇    下一篇

PCT、hsCRP和WBC检测在儿童呼吸系统感染中的应用

邓耀明   

  1. 412000 湖南株洲市，株洲市妇幼保健院检验科
  • 出版日期:2016-12-10 发布日期:2017-01-02

PCT and hs-CRP levels and WBC count in predicting respiratory tract infections in children

Deng Yaoming   

  1. Department of Clinical Laboratory, Women and Children Healthcare Hospital of Zhuzhou, Zhuzhou 412000, China.
  • Online:2016-12-10 Published:2017-01-02

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被引次数

2

摘要： 目的  探讨降钙素原（PCT）、超敏C反应蛋白（hsCRP）和白细胞（WBC）检测在儿童呼吸系统感染中临床意义。 方法  选取2014年5月至2015年8月在本院治疗的呼吸系统感染的儿童150例，其中细菌性感染的80例（G+菌感染43例，G-菌感染37例），非细菌性感染70例，另选取同期在医院健康体检的儿童46例做为对照组，分别比较各组PCT、hsCRP和WBC的水平及各指标在儿童呼吸系统感染中的诊断价值。 结果  细菌感染组PCT、hsCRP和WBC的水平高于非细菌感染组和对照组，差异显著（P<0.05），非细菌感染组PCT、hsCRP和WBC血液水平与对照组比较差别不明显，没有统计学意义（P>0.05）；PCT、hsCRP和WBC水平检测在儿童呼吸系统感染性疾病诊断中，PCT的灵敏度和特异度高于hsCRP和WBC两个指标，联合检测可以提高诊断的敏感度；G-菌感染者PCT水平明显高于G+菌感染者（P<0.05），hsCRP和WBC水平在两组之间差别不显著（P>0.05）。 结论  PCT、hsCRP和WBC是儿童呼吸系统感染最常用的检测指标，PCT较hsCRP、WBC具有良好的灵敏度和特异度，能为细菌性和非细菌性感染及G+和G-菌感染的鉴别诊断提供一定参考。

关键词: 降钙素原, 超敏C反应蛋白, 白细胞, 呼吸系统, 感染

Abstract:

Objective  To assess the clinical values of measuring procalcitonin(PCT) and high-sensitive-C reactive protein(hsCRP) levels and white blood cell(WBC) count for prediction of the respiratory tract infections in children. Methods  150 children with respiratory tract infections treated in our hospital were included from May 2014 to August 2015 as case group, in whom 80 were bacterial infection(Gram-positive infections in 43, Gram-negative in 37) and 70 were nonbacterial infection. Another 46 healthy children undergoing physical examination in the corresponding period were selected as control group. Levels of PCT and hs-CRP as well as WBC count were measured in both groups and compared for evaluating the values of the indicators in predicting respiratory tract infections in children. Results  Children in bacterial infection group had higher PCT and hs-CRP levels and WBC count than those in nonbacterial infection group and control group (P<0.05), yet the nonbacterial infections group and control group remained no significant difference regarding the levels of PCT and hs-CRP and WBC count (P>0.05). Of the three indicators, PCT level had higher sensitivity and specificity than hsCRP level and WBC count in predicting the respiratory tract infection, and combined measurement of the three indicators can improve the general sensitivity. Children with Gram-negative bacterial infection had significantly level than those infected with Gram-positive bacteria(P<0.05), yet hsCRP level and WBC count were not significantly different between the two groups (P>0.05). Conclusion  PCT and hs-CRP level and WBC count can be the common indicators for predicting respiratory tract infections in children, however, PCT has higher sensitivity and specificity than hsCRP measurement and WBC count. These findings may be differential role in bacterial and non-bacterial infection as well as Gram-positive or negative infection.

Key words: Procalcitonin, High-sensitive-C reactive protein, White blood cell, Respiratory system, Infection