热带病与寄生虫学

热带病与寄生虫学 ›› 2025, Vol. 23 ›› Issue (6): 369-372,381.

• 防治研究 • 上一篇    下一篇

2015—2024年合肥市丙型病毒性肝炎流行特征分析

董婷丽，李玮，姚晖，冯金保，孙静，孙新，滕影，余雪敏，张琳琳，胡中旺   

  1. 合肥市疾病预防控制中心，安徽 合肥 230041
  • 收稿日期:2025-09-17 出版日期:2025-12-20 发布日期:2026-01-23
  • 通信作者: 姚晖，E-mail: hfcdcyaohui@126.com
  • 作者简介:董婷丽，女，硕士，医师，研究方向：艾滋病、丙肝和性病预防控制。E-mail: 1329978007@qq.com
  • 基金资助:
    合肥市卫生健康委应用医学科研项目（Hwk2024yb023）

Epidemiological characteristic of hepatitis C in Hefei City from 2015 to 2024

DONG Tingli, LI Wei, YAO Hui, FENG Jinbao, SUN Jing, SUN Xin, TENG Ying, YU Xuemin, ZHANG Linlin, HU Zhongwang   

  1. Hefei Center for Disease Control and Prevention, Hefei 230041, Anhui Province, China
  • Received:2025-09-17 Online:2025-12-20 Published:2026-01-23

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摘要： 目的 了解近年来合肥市丙型病毒性肝炎（简称丙肝）流行特征，为合肥市丙肝防治提供科学依据。方法 通过中国疾病预防控制信息系统获取2015—2024年合肥市的丙肝病例个案资料，使用描述流行病学方法分析合肥市丙肝患者的流行病学特征；利用Joinpoint回归模型分析发病率变化趋势，计算年变化百分比（annual percent change, APC）和平均年变化百分比（average annual percent change, AAPC）。结果 2015—2024年合肥市累计报告丙肝病例5 868例，年均报告发病率为6.84/10万，总体发病率呈下降趋势，AAPC为-7.47%（95%CI：-9.87%～-5.01%）（t=-5.80，P<0.001）。其中，2015—2019年呈上升趋势，APC为5.41%（95%CI：1.14%～9.87%）（t=5.48，P<0.05）；2022—2024年呈下降趋势，APC为-26.51%（95%CI：-37.36%～-13.77%）（t=-8.29，P<0.05）。2015—2024年合肥市丙肝病例以确诊病例为主（3 328例，占56.71%）。男性3 095例，女性2 773例，性别比为1.12∶1；主要集中在50岁及以上年龄组（3 534例，占60.22%）；职业以农民（1 918例，占32.69%）和家务及待业（1 705例，占29.06%）为主。合肥市丙肝病例全年均有报告，3月份报告病例数最多（578例，占9.85%）。年均报告发病率前3位的县区分别是庐阳区（9.59/10万）、肥西县（9.02/10万）和瑶海区（8.58/10万）。380例丙肝病例进行了基因型检测，基因型以1b型为主（279例，占73.42%）。结论 合肥市丙肝报告发病率总体呈下降趋势，庐阳区发病率最高，男性、中老年、农民群体是高发人群。在今后丙肝防控工作中，应加强重点地区及人群的监测和宣教。

关键词: 丙型病毒性肝炎, 流行特征, 时间趋势, 合肥市

Abstract: Objective To understand the epidemiological characteristics of hepatitis C in Hefei area in recent years for scientific basis in local prevention and treatment of hepatitis C. Methods The case data of hepatitis C patients with current address in Hefei from 2015 to 2024 were obtained from the Chinese Disease Prevention and Control Information System. Descriptive epidemiological methods were used to analyze the epidemiological characteristics of hepatitis C patients in Hefei area. The Joinpoint regression model was used to analyze the trend of incidence, and the annual percent change (APC) and the average annual percent change (AAPC) were calculated. Results From 2015 to 2024, a total of 5 868 hepatitis C cases were reported in Hefei, with an average annual reported incidence rate of 6.84/100 000. The overall incidence rate showed a downward trend, and the AAPC was -7.47% (95%CI:-9.87% - -5.01%) (t=-5.80, P<0.001). During that period, the APC was 5.41% (95%CI: 1.14% - 9.87%) (t=5.48, P<0.05) from 2015 to 2019, and -26.51% from 2022 to 2024 (95%CI:-37.36% - -13.77%) (t=-8.29, P<0.05). From 2015 to 2024, the majority of hepatitis C cases in Hefei were confirmed cases (n=3 328; 56.71%). Of the reported cases, 3 095 were males, and 2 773 females,  with a sex ratio of 1.12∶1. The cases were mainly reported in the age group of 50 years and above (n=3 534; 60.22%). The occupation was primarily involved in farmers (n=1 918; 32.69%) and housework and unemployed (n=1 705; 29.06%). Hepatitis C cases were reported throughout the year in Hefei area, with the highest number of cases reported in March (n=578; 9.85%). The top three counties with the highest incidence rates were Luyang (9.59/100 000), Feixi (9.02/100 000) and Yaohai (8.58/100 000). A total of 380 hepatitis C cases were detected for genotypes, which was dominated by genotype 1b (n=279; 73.42%). Conclusion The overall reported incidence of hepatitis C in Hefei area showed a downward trend, and the highest incidence was seen in Luyang district. Men, middle-aged and elderly people and farmers were high-risk groups. By these findings, it is necessary to strengthen the surveillance and health education in key areas and populations in following tasks.

Key words: Hepatitis C, Epidemiological characteristic, Time trend, Hefei City

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