热带病与寄生虫学

热带病与寄生虫学 ›› 2022, Vol. 20 ›› Issue (6): 352-356.

• 综述 • 上一篇    

寄生虫对肠道菌群和宿主免疫功能影响的研究进展

朱维1，高雷明2，刘海霞3，米荣升3，李宗杰3   

  1. 1.滕州市动物疫病预防控制中心，山东 枣庄 277599；  2.临沭县疾病预防控制中心； 3. 中国农业科学院上海兽医研究所
  • 收稿日期:2022-05-11 出版日期:2022-12-20 发布日期:2023-01-19
  • 作者简介:朱维，男，硕士，兽医师，研究方向：动物疫病预防与控制。E-mail：lyzw521@126.com
  • 基金资助:
    新疆少数民族科技人才特殊培养计划（2020D03030）

Research progress on the influence of parasite on intestinal flora and host immune function

ZHU Wei1, GAO Lei-ming2, LIU Hai-xia3, MI Rong-sheng3, LI Zong-jie3   

  1. 1. Tengzhou Animal Disease Prevention and Control Center, Zaozhuang 277599, Shandong Province, China; 
    2. Linshu County Disease Prevention and Control Center; 
    3. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science (CAAS)
  • Received:2022-05-11 Online:2022-12-20 Published:2023-01-19

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摘要： 摘要：寄生虫、肠道菌群和宿主三者之间存在错综复杂的相互作用，寄生虫感染宿主后不仅可以通过分泌物或排泄物直接改变宿主的肠道菌群，还可以通过调节宿主的免疫细胞和免疫器官的功能，进一步影响宿主免疫性疾病的发生和发展。本文综述了寄生虫感染对宿主肠道菌群的物种多样性和群落结构的影响，以及寄生虫感染对宿主免疫稳态和免疫性疾病的影响，通过探讨寄生虫感染对宿主肠道菌群的作用机制，以期为调控肠道菌群靶向治疗寄生虫病提供参考。

关键词: 寄生虫, 肠道菌群, 宿主, 免疫稳态, 免疫性疾病

Abstract: Abstract: The interactions among parasites, intestinal flora and hosts are intricate, and parasite infection can not only alter the host's intestinal flora through the secretions or excretions in direct fashion, but also regulate the functions of host immune cells and immune organs, further affecting the development and progression of immune disorders of the hosts. This paper primarily reviews the impacts of parasitic infection on the species diversity and community structure of host intestinal flora, as well as the effects of parasitic infection on the immune homeostasis and immune diseases of the hosts. In addition, the action mechanism of parasitic infection on host intestinal flora was investigated, with an attempt to provide a reference for the treatment of parasitic diseases on targeting intestinal flora basis.

Key words: Parasite, Gut microbiome: Host, Immune homeostasis, Immunological disease

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