Objective　To understand the endemic status of Clonorchis sinensis infection in Guangxi area for evidences to develop scientific prevention and control measures for this parasite infection. Methods　Six counties (cities or districts) were selected as regular surveillance sites according to the epidemic severity of Clonorchis sinensis infection in Guangxi. Each monitoring site was divided into 5 areas by geographical location(east,west,south,north and middle areas),where one administrative village(community) was then selected from a township to serve as the surveillance site. By cluster sampling,200 permanent residents(a total of 1 000) aged over 3 years were annually included from individual village(community) to undergo fecal examination using modified Kato-Katz thick smear method for the count of Clonorchis sinensis eggs,and other parasitic eggs were maintained if detected in the test. The surveillance lasted for five years(from 2016 to 2020),and covered all population group ranging from children,adults,middle-aged and the elderly. Results　The infection rate of Clonorchis sinensis per year was 11. 98%(756/6 308),6. 32%(394/6 230),10. 97%(670/6 110),10. 03%(680/6 781) and 7. 96%(497/6 242),respectively,which showed a declined trend from 2016 to 2020(χ 2 =13. 627,P<0. 01). The infection rate in each year is commonly higher in males than in females,and the highest in population aged between 40 and 49,50 and 59 years old. The infection was increased with added educational level,yet was generally mild. The infection rate of soil-transmitted nematodes was 2. 46%(155/6 308),2. 30%(143/6 230),1. 34%(82/6 110),1. 11%(75/6 781) and 0. 72%(45/6 242),respectively in the five years,and tended to decrease year by year(χ 2 =88. 378,P<0. 01). Hookworm infection was dominate in each year among other parasites. Conclusion　Infection of Clonorchis sinensis remains in a higher endemic level in Guangxi,which suggests that clonorchiasis should be the key in following prevention and control of the parasitic disease.