Objective　To analyze the surveillance results of soil-transmitted nematode diseases and key food-borne parasitic diseases in Shanghai between 2016 and 2020 for scientific basis to formulate prevention and control strategies on a city-level.Methods　By stratified clustering sampling technique,we conducted a series of monitoring over the prevalence of soiltransmitted nematode diseases at regular and non-regular surveillance sites, clonorchiasis by moving observation in Shanghai area. Modified Kato-Katz thick smear technique was applied to detecting the eggs of soil-transmitted nematodes and Clonorchis sinensis. The surveillance results of food-borne parasitic diseases were retrospectively analyzed in this study based on the cases reported through hospital information system. Results　No positive cases were found in a total of 5 106 people from the mobile surveillance sites undergone clonorchiasis screening between 2016 and 2020. Also from 2016 to 2020,a total of 24 843 people/ person-times in regular and mobile surveillance sites received detection of the soil-transmitted nematode diseases. An investigation conducted in 2016 revealed infection with soil-transmitted nematode diseases in 7 out of the 6 240 people(including roundworm in 5;whipworm in 2;no hookworm and pinworm were found). The infection rate of 2016 was 0. 11%,and no infection was found in other years.Totally,138 hospitalized cases of food-borne parasitic diseases were obtained through hospital information reporting system. Clonorchiasis and paragonimiasis infection accounted for 30. 43% (42/138) and 25. 36% (35/138),respectively. Fifty-seven cases(41. 30%) were patients currently living in Shanghai,and 81(58. 70%) were patients seeking medical treatment in Shanghai from other provinces,in which the patients from Zhejiang,Anhui,Jiangsu and Jiangxi accounted for 60. 50% of the total cases. Conclusion　The infection rate of soil-transmitted nematodes in Shanghai has dropped to a relatively lower level. The following prevention and control strategies can be focused on gradual evaluation on the transmission interruption as well as strengthened surveillance over the food-borne parasitic diseasesand related food hygiene and safety management.