Abstract: Objective To assess the effect of perioperative nursing intervention in patients of advanced schistosomiasis with severe hypersplenism.Methods One hundred and thirty-eight patients of advanced schistosomiasis with splenomegaly were divided into observational group and control group(n=69 for each group).Patients in the control group received simple conventional nursing,and those in the observational group were nursed with additional psychological intervention,diet and drainage-tube management as well as prevention of the complications on routine nursing basis.Results There was no significant difference in on the Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) between the two groups on admission (P >0.05),yet scoring on SAS and SDS was lower in observational group than in control group after surgery (P <0.05).Patients in the observational group had earlier anal exhaust,off-bed activities and bowel movement as well as lower incidence of short-term complications,shortened hospital stay and medical expenses than those in the control group(all P <0.05).Conclusion Perioperative nursing intervention for patients of advanced schistosomiasis with severe hypersplenism can effectively improve their psychological
state,reduce the incidence of complications and promote early recovery.

Key words: Advanced schistosomiasis , Severe hypersplenism , Perioperative nursing