Abstract: Objective To prevent the occurrence of new cases of advanced schistosomiasis,ensure the health of residents in endemic areas and help them to overcome poverty by following the clue cases of advanced schistosomiasis. Methods According to the relevant requirements specified in the Work Plan for Investigation of Current Cases and Clue Cases of Advanced Schistosomiasis in Anhui Province,we carried out a survey on the clue cases of schistosomiasis previously identified in 7 endemic villages and towns in Yi'an District of Tongling City.All subjects undergone survey were decided by the results of IHA test and treatment history,and the clue survey was comprehensively estimated by the findings of physical examination,imaging examination and laboratory studies.Results Totally,630 cases of advanced schistosomiasis were initially screened by looking up the medication records and epidemiological history of the residents in 2018.Further B-ultrasound examination and laboratory testing revealed that 5 patients were clinically diagnosed advanced schistosomiasis,and 80 were suspected advanced schistosomiasis.Conclusion Although the current epidemic situation of schistosomiasis in our region has dropped to the lowest level in history,yet the pathological damage of schistosomiasis to human body still exists,and some infected patients remains in risks to develop into advanced disease.Therefore,it is of great significance to carry out the clue screening of advanced schistosomiasis in order to reduce new cases of advanced schistosomiasis.

Key words: Advanced schistosomiasis, Clue investigation , Yi'an Distric