热带病与寄生虫学

热带病与寄生虫学 ›› 2015, Vol. 13 ›› Issue (3): 169-171.doi: 10.3969/j.issn.1672-2302.2015.03.014

• 论著 • 上一篇    下一篇

日本血吸虫病低度流行区吡喹酮薄膜衣片临床疗效及不良反应评价

卢萍，尤璐，华海涌   

  1. 214064  江苏无锡市，江苏省血吸虫病防治研究所、国家卫生和计划生育委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫分子生物学重点实验室
  • 出版日期:2015-09-10 发布日期:2015-09-30

Evaluation on the therapeutic efficacy and adverse effects of film-coated praziquantel tablet against Schistosoma japonicum infection in low-endemicity areas

 Lu Ping, You Lu, Hua Haiyong   

  1. Jiangsu Institute of Parasitic Diseases. Key Laboratory on Technology for Parasitic Disease Prevention and Control, National Health and Family Planning Commission. Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 214064, China.
  • Online:2015-09-10 Published:2015-09-30

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摘要： 【摘要】 目的  评价日本血吸虫病低度流行区吡喹酮薄膜衣片对血吸虫病患者的疗效。 方法  选择1 个血吸虫病低度流行村，对5~60岁常住居民采用毛蚴孵化法进行粪检，并统计患者感染度（EPG）。阳性者分别采用60mg/kg 或40mg/kg 吡喹酮薄膜衣片进行病原学治疗。治疗6 周后粪检复查，评估吡喹酮薄膜衣片疗效，阳性者采用相同治疗进行第2 次治疗；同时观察吡喹酮服药后的不良反应发生情况。 结果  87 例观察对象中，有吡喹酮抗虫治疗史1 次者43例，2 次以上者44例；中度感染37例（EPG：216~312），轻度感染50例（ EPG：24~96）；第1 次治疗使用吡喹酮薄膜衣片60mg/kg 37例，40mg/kg 50例，复查均未查见毛蚴或虫卵。患者不良反应发生率为17.24%。 结论  在日本血吸虫病低度流行区，吡喹酮薄膜衣片对血吸虫感染者具有较高敏感性。

关键词: 日本血吸虫病, 吡喹酮薄膜衣片, 敏感性, 疗效

Abstract:

【Abstract】 Objective  To evaluate the therapeutic efficacy of film-coated praziquantel tablet in the treatment of patients infected with Schistosoma japonicum(S. japonicum) in areas with low endemicity. Methods  The dwellers aged 5 to 60 years from villages of low endemicity received stool examination for the S. japonicum infection using miracidium hatching test, and the positive cases were given etiological intervention with film-coated praziquantel tablet in dose of 60 or 40 mg/kg. Miracidium hatching test was performed after 6 weeks of medication to assess the therapeutic efficacy, and those that remained positive underwent the second treatment using the same protocol. All adverse events associated with praziquantel treatment were observed. Results  Of the 87 subjects, 43 had a history of once praziquantel treatment, and 44 a history of twice or over. Thirty-seven cases had moderate infection (EPG, 216-312), and 50 mild infection (EPG, 24-96). Re-examination with miracidium hatching test detected no S. japonicum miradium or egg following treatment with film-coated praziquantel tablet in dose of 60 mg/kg in 37 cases and 40 mg/kg in 50 cases. The incidence of adverse reactions was 17.24%. Conclusion  The therapeutic efficacy of film-coated praziquantel tablet remains sensitive to patients infected with S. japonicum in areas with low endemicity.

Key words: Schistosomiasis japonica, Film-coated praziquantel tablet, Sensitivity, Therapeutic efficacy