Abstract: UDP-glucuronosyltransferases (UGTs), an important phase Ⅱ metabolic enzyme and highly expressed in the liver, plays pivotal role in the metabolism and clearance of substances. Therefore, transcriptional regulation of UGTs is critical for the occurrence and development of liver diseases. This paper aims at reviewing the general families of UGT and their relationship with metabolism, and investigating the expression and transcriptional regulation of UGTs in liver disease, as well as the study of UGTs in disease mechanism and implications of UGTs in clinical treatment of liver disease. 

Key words: UDP-glucuronosyltransferases（UGTs）, Liver disease, Phase Ⅱ metabolic enzymes, Schistosoma