Abstract: This article summarizes the diagnosis and nursing experience in one patient with severe COVID-19 received high-flow nasal cannula(HFNC) oxygen therapy. The authors concluded that HFNC was an effective strategy to improve respiratory distress and other symptoms in patients with severe COVID-19. Nursing process should consist of monitoring of the patient’s vital signs and oxygenation, and opportune adjustment of HFNC parameters by the arterial blood gas analysis and patient’s clinical picture. In addition, the patient should be provided with enough communication and humanistic care in order to timely improve his bad mood and early recovery.

Key words: Severe COVID-19, High-flow nasal cannula oxygen therapy, Nursing