Abstract:

Objective To study the effect and security of Phentolamine on chronic pulmonary heart disease with right ventricular dysfunction. Methods 92 cases with chronic pulmonary heart disease and right ventricular dysfunction in the 105th Hospital of PLA from June 2012 to June 2013 were selected and divided into two groups randomly. The control group (46 patients) was treated by spasmolysis, cardiac, expectorant, infection control and improvement of heart function, and the treatment group by the same therapies as control group and intravenous infusion of phentolamine(20mg) additionally. The treatment duration of the two groups
were all 10 days. Then the cardiac function, pulmonary artery pressure and right ventricular diameter change of the two groups between pre-treatment and post-treatment were analyzed, the effect of Phentolamine was evaluated and the rate of adverse reaction were observed. Results There were significant differences of cardiac function, pulmonary artery pressure and right ventricular diameter between pre-treatment and post-treatment of the two groups (P<0.05). The effective rate of treatment group (91.30% ) was higher than control group (80.43%) (P<0.05), and there was no significant difference in the adverse action between the two groups (P>0.05). Conclusion The conventional therapy plus phentolamine on treatment of chronic pulmonary heart disease with right ventricular dysfunction was efficacious, safe and worthy of promotion.

Key words: Phentolamine, Chronic pulmonary heart disease, Right ventricular dysfunction, Effect