Objective　To evaluate the prevention and control effect in compliance with the criteria of transmission interruption of schistosomiasis in 27 counties of Hubei Province during the 13th Five-year Plan. Methods　According to the Evaluation Scheme for Interrupting Schistosomiasis Transmission at County Level in Hubei Province,we conducted an assessment and evaluation on the outcomes in areas where the transmission interruption reached the criteria in Hubei Province. Results　Serum examination on the schistosome was performed in 88 483 residents living in the 27 counties(cities/ districts), which revealed positive rate of 1. 88%(0~6. 78%). Stool examination carried out 1 665 people showed no infection. A total of 1 289 heads of cattle and sheep underwent examinations. No infection was detected. Field survey was carried out at 162 680 frames,where 36 382 snails were captured. No infection was found in the 25 566 living snails that were dissected. Full set of archives were established on schistosomiasis control based on individual administrative village. The documentation can well reflect the changes of human and animal infection from transmission control to transmission interruption. In addition, this practice represented a sensitive and effective monitoring system that was commensurate with local epidemic nature. Conclusion　The 27 counties in Hubei Province have successfully reached the target and national criteria of transmission interruption of schistosomiasis defined in the 13th the Five-year Plan of China.