Abstract: Schistosoma mansoni and Schistosoma japonica are two major pathogens of intestinal schistosomiasis worldwide. Primary pathology of the infection involved in these two parasites is designated by the egg-induced liver granuloma and fibrosis,yet the difference is significant in oviposition mode and constituent cells of the granuloma between the two infections. At resent, Schistosoma japonicum is the major study interest in China,whereas Schistosoma mansoni  is intensively investigated in foreign countries,and few reviews are available on the differences between the two kinds of schistosomiasis. In order to better understand the pathology diversity between Schistosoma japonicum and Schistosoma mansoni infection,this paper reviewed the pathological differences of the two parasites from six aspects,including the genome and evolutionary pathway of Schistosoma, larval migration,parasitic location and oviposition mode of adults,local histopathological findings,mechanisms of granulomatous formation and cell composition.

Key words: Schistosoma japonicum , Schistosoma mansoni , Egg granuloma, Pathogenic difference