Abstract:

Objective To study the influence of dexmedetomidine (DEX) in the hemodynamic and analepsia quality of elderly patients with combined general anesthesia for total hip replacement, and to provide theoretical basis for its application in clinic. Methods From May, 2006 to May, 2013, 60 ASA I- II elderly patients undergoing total hip replacement with combined general anesthesia were randomly divided into the DEX treatment group and control group. The patients in the DEX treatment group were pumped with 0.3 μg· kg-1· h-1 DEX. The patients in the control group were pumped with 0.9% NaCl. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and cerebral state index (CSI) of patients in various group before administration (T0), at the beginning of pump delivery (T1), at 10 min after pmp delivery (T2), at the beginning of skin incision (T3), at 30 min after skin incision (T4), at extubation (T5), 30 min after extubation (T6) were recorded. The wake-up time, extubation time and Observer’s Assesment of Alterness/sedation scores (OAA/S) at 30 min after operation. Results Compared with the control group, at T5, T6, the SBP, DBP and HR in the treatment group were descended significantly, there were statistically significant differences (P<0.05). Compared with the control group, The CSI at T2 to T6 in the the DEX treatment group were descended significantly, there were statistically significant differences (P<0.05). Compared with the control group, the wake-up time, extubation time in the DEX treatment group were reduced significantly, and there were statistically significant differences (P<0.05). Compared with the control group, the OAA/S of patients in the DEX treatment group increased significantly, and there was statistically significant differences (P<0.05). Conclusion The DEX treatment could stablize the hemodynamics indexes of elderly patients with general anesthesia during extubation, shorten the time of analepsia and extubation, and sustain OAA/S.

Key words: Dexmedetomidine, General anesthesia, Total hip replacement, Hemodynamic, Analepsia quality