热带病与寄生虫学

热带病与寄生虫学 ›› 2016, Vol. 14 ›› Issue (2): 71-73.doi: 10.3969/j.issn.1672-2302.2016.02.003

• 论著 • 上一篇    下一篇

2015年宿州市324例手足口病病原检测结果分析

张玲，葛明明   

  1. 234000 安徽宿州市，宿州市疾病预防控制中心
  • 出版日期:2016-06-10 发布日期:2016-07-11

Analysis on the etiology monitoring results in 324 cases of hand-foot-mouth disease in Suzhou in 2015 

Zhang Ling, Ge Mingming   

  1. Suzhou Center for Disease Control and Prevention, Suzhou 234000, China.
  • Online:2016-06-10 Published:2016-07-11

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摘要： 【摘要】 目的  了解2015年宿州市手足口病病原学流行特征，为制订手足口病防控方案提供依据。 方法  采用Real-time RT-PCR方法检测肠道病毒71型（EV71）、柯萨奇病毒A组16型(CoxA16)的特异性核酸及其它肠道病毒核酸（非EV71和非CoxA16）。 结果  324份手足口病临床诊断病例标本，肠道病毒核酸总阳性137份，阳性率42.3%。EV71阳性35份，阳性率10.8%（35/324），阳性构成比为25.5%（35/137）；CoxA16阳性26例，阳性率8.0%（26/324），阳性构成比为19.0%（26/137）；其他肠道病毒（非EV71和非CoxA16）76份，阳性率23.5%（76/324），阳性构成比为55.5%（76/137）。男女比为1.6︰1，男性和女性阳性率分别为43.4%(86/198)和39.7%（50/126），男女阳性检出率差异无统计学意义(χ2=0.445，P>0.05)；发病年龄组以0~3岁为主；1月及4~7月为发病高峰，阳性检出率均超过50%。 结论  2015年宿州市手足口病发病高峰在春夏季，3岁以下儿童为高发病人群，其流行型别以其他肠道病毒（非EV71和非CoxA16）为主，同时伴有EV71和CoxA16。

关键词: 手足口病, 肠道病毒, 病原检测

Abstract:

【Abstract】 Objective  To investigate the etiological properties and pathogen distribution in hand-foot and mouth disease(HFMD) in Suzhou area in 2015 for evidences to plan strategies in prevention and control of HFMD prevalence. Methods  Real-time PCR was used to detect the enterovirus 71(EV71), specific nucleic acid in Coxasckie virus A16(CoxA16) and in other enteroviruses(Non-EV 71 and Non-CoxA16). Results  In 324 samples clinically diagnosed as HFMD, 137(42.3%) were found with positive nucleic acid. Thirty-five positive samples were associated with EV 71 infection(10.8%, 35/324), and the constituent ratio was 23.5%(35/137). Twenty-six samples were involved in CoxA16 infection, with positive rate of 8.0%(26/324) and positive ratio of 19.0%(26/137). Another 76 samples were associated with other enterovirus infection(Non-EV 71 and Non-CoxA16). The positive rate was 23.5%(76/324), and positive ratio, 55.5%(76/327). The infection ratio of male to female was 1.6:1, and the positive rate was 43.4%(86/198) and 39.7%(50/126) with no significant difference(χ2=0.445, P>0.05). The patients aged from 0 to 3 years were mostly affected, HFMD prevalence was peaked in January and April through July, in which period the positive rate was over 50%. Conclusion  The peak prevalence of HFMD was observed in spring, summer and autumn seasons in Suzhou area in 2015, and children under 3 years are mostly affected. The enteroviruses are primarily associated with other pathogens except for infection with EV 71 and CoxA16.

Key words:  Hand-foot-mouth disease, Enterovirus, Pathogen detection