Abstract: Abstract: The interactions among parasites, intestinal flora and hosts are intricate, and parasite infection can not only alter the host's intestinal flora through the secretions or excretions in direct fashion, but also regulate the functions of host immune cells and immune organs, further affecting the development and progression of immune disorders of the hosts. This paper primarily reviews the impacts of parasitic infection on the species diversity and community structure of host intestinal flora, as well as the effects of parasitic infection on the immune homeostasis and immune diseases of the hosts. In addition, the action mechanism of parasitic infection on host intestinal flora was investigated, with an attempt to provide a reference for the treatment of parasitic diseases on targeting intestinal flora basis.

Key words: Parasite, Gut microbiome: Host, Immune homeostasis, Immunological disease