Abstract: Objective  To assess the value of percutaneous cholecystectomy (PC) in the treatment of acute cholecystitis in patients with advanced schistosomiasis. Methods  The clinical data, including the time consumed in intubation, the time of clinical symptom remission and catheter retained, were collected and analyzed in 17 patients with advanced schistosomiasis complicated with acute cholecystitis treated in our hospital between January 2016 and January 2021. The serum related inflammation and liver function indexes before and 72 hours after the operation were compared and analyzed. Results  Puncture and catheterization was successful at one time. Catheterization consumed (14.1±4.3) min. Remission of the clinical symptom was (54.2±9.8) h, and the catheter was retained for (19.0±5.4) d. Preoperative serum inflammatory indicators, including leukocyte count, percentage of neutrophil, high-sensitivity C-reactive protein, procalcitonin and interleukin-6 were 20.6 (18.2，23.7)×109 /L, (81.2±12.4)%, (140±15) mg/L, (0.46±0.13) ng/mL and (176±25) pg/mL, respectively. The above serum related inflammatory indicators were 13.2(11.5，16.6)×109/L, (69.9 ± 15.8)%, (81±14) mg/L, (0.34 ± 0.12) ng/mL and (135 ± 25) pg/mL, respectively, at 72 h after operation. The difference was significant compared to those before operation (Z =-3.962; t =2.261, 14.259, 3.592, 6.432, respectively, all P<0.05). Major preoperative liver function related indicators, including alanine aminotransferase γ-glutamyltranspeptidase, aspartate aminotransferase, serum total bilirubin, and serum total protein were 52.0 (30.0, 85.5) U/L, 62.5 (40.0, 83.3) U/L, 43.0 (21.0, 59.0) U/L, 19.9 (15.5, 30.4) μmol/L and (54.0 ± 9.7) g/L, respectively. At 72 h after operation, the main indexes related to liver function were 51.0 (28.3, 80.5) U/L, 58.0 (38.5, 84.5) U/L, 41.9 (19.5, 50.0) U/L, 16.1 (14.7, 25.7) μmol/L, and (68.4 ± 10.3) g/L, respectively. Compared with those before operation, the differences in serum total bilirubin and serum total protein were statistically significant (Z =-2.150; t =3.603, all P<0.05). Conclusion  The intraperitoneal PC is safe and effective for patients with advanced schistosomiasis complicated with acute cholecystitis, and has a positive impact on the late treatment of such patients.

Key words: Percutaneous cholecystectomy, Advanced schistosomiasis；Acute cholecystitis；Treatment