Abstract: Objective To understand the basic information of death of patients with advanced schistosomiasis in Jinshan district,and analyze the causes of death for evidences to scientifically plan dynamic management strategies and specific treatment program for such patients. Methods The information was retrieved through follow-up of database of patients with advanced schistosomiasis from 2007 to 2019 in Jinshan district. The causes of death were analyzed pertinent to the death trend in patients with advanced schistosomiasis as well as the registered advanced cases in history and newly diagnosed advanced cases across the district. Results Death of advanced schistosomiasis patients was increased in fluctuant fashion in Jinshan district from 2007 to 2019. In early 2007,registered advanced cases were 1 121,and newly diagnosed advanced patients were 280 between 2007 and 2019. Totally,643 patients died of advanced schistosomiasis during 2007-2019,in whom 264 were males and 379 females. The age of the dead ranged from 50 to 97 years old,with a mean age of (76. 51±8. 45) years. The mortality was significantly higher in the newly diagnosed advanced patients than in those of registered in history ( χ2 = 53. 02,P<0. 01),and higher in females than in males( χ2 = 31. 39,P<0. 001). The top three causes of death in newly diagnosed advanced patients were associated with sequela and complications of schistosomiasis,liver cancer and cardiovascular and cerebrovascular diseases,which accounted for 57. 92%,16. 39% and 9. 29%,respectively. The top three causes for the death of historically registered advanced patients were involved in cardiovascular and cerebrovascular diseases,sequela and complications of schistosomiasis and other cancers,which accounted for 29. 78%,18. 04%,and 16. 52%,respectively. Conclusion Sequelae and complications of schistosomiasis,cardiovascular and cerebrovascular diseases,and liver cancer were the main causes responsible for the death of advanced schistosomiasis patients in Jinshan district during 2007- 2019. This suggests that treatment of such patients should be carried out according to the real condition by establishing a sound and effective care system for patients with advanced schistosomiasis.

Key words: Advanced schistosomiasis, Cause of death, Jinshan District