Abstract: Objective To investigate the status of TORCH infection in children with hematological diseases in the First Affiliated Hospital of USTC (Western District),Anhui Provincial Cancer Hospital. Methods 354 children treated in the Department of Pediatric Hematology of our hospital were included from November 2015 to July 2019. Blood samples were obtained from all children, and detected for the TORCH-IgG and IgM using chemiluminescence immunoassay. Then the TORCH infection pattern, age distribution and disease types were analyzed in the 354 patients. Results TORCH test showed that the positive rate was 0. 6%,4. 2% and 7. 3% for Toxoplasma-immunoglobulin M (TOX-IgM),rubella virus-IgM (RV-IgM) and cytomegalovirus-IgM (CMV-IgM),and 21. 2%,88. 1%,91. 2%,49. 2% and 15. 8% for TOX-IgG,RV-IgG, CMV-IgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG,respectively. Co-infection of CMV+RV occurred in one child. The infection rate of RV-IgM( +),CMV-IgM( +), RV-IgG( +),HSV-Ⅰ-IgG( +) or HSV-Ⅱ-IgG( +) was significantly different in different age group. Chi square trend test showed that the positive rates of RV-IgM,CMV-IgM and HSV-Ⅱ-IgG decreased with the age of children,while the positive rates of RV-IgG and HSV-Ⅰ-IgG increased with the age of children. The positive rate of TOXIgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG was significantly different in children with diverse type of infection. Conclusion TORCH-IgG and IgM detection in children with hematological diseases can identify the type of infection and previous infection,and provide help for the diagnosis and treatment of hematological diseases.

Key words: TORCH infection, Childhood hematopathy, Toxoplasma gondii, Rubella, Cytomegalovirus, Herpes simplex virus