Abstract: Objective To analyze the distribution of advanced schistosomiasis and evaluate the therapeutic effect in Guichi district in 2012. Methods According to the list of patients with advanced schistosomiasis determined by the provincial and municipal experts, the information about the therapeutic effect was collected and analyzed in 2012. Results Among 575 alive advanced schistosomiasis patients, the sex ratio of male and female was 1.22:1, 83.83% of the patients were older than 55 years old, 89.2% were primary school education degree, and 92.7% were farmers. 64.35% of the patients with ascites, and 32.9% with splenectomised. The average survival time after operation was 19 years. 77.92% of the patients were living in the villages which had reached transmission interruption, and 60% were from Lake endemic areas. The average age of the patients who were diagnosed firstly as schistosomiasis and advanced schistosomiasis was 22.7 and 55.1 years old, respectively. 12.87% of the patients were complicated with HBV infection. 98.61% of the patients accepted the antischistosoma therapy. 97.1% of the patients got better after treatment. 10 cases died, and 70% of them died from upper gastrointestinal hemorrhage, hepatic coma and other complications. Conclusion The patients with advanced schistosomiasis were mainly distributed in heavy endemic areas, and most of the them were farmers, old ages, lower education degree, long course of disease, and the therapeutic effect was obvious.

Key words: Advanced schistosomiasis, Distribution, Therapeutic effect