Abstract: Objective  To analyze the clinical characteristics of leptospirosis complicated with liver dysfunction retrospectively.  Methods  From April of 2010 to March of 2013,12 cases of leptospirosis complicated with liver dysfunction which had holonomic information were collected and analyzed.  Results  All cases had liver dysfunction and 66.7% had gastrointestinal manifestations (8/12). The level of ALT and AST all increased in the cases and 4 cases were more than U/ml. 5 cases (41.7%) had higher level of TBil, of which 3 cases were more than 171µmol/ml. Prothrombin time (PT) of 6 cases (50.0%) prolonged, prothrombin activity (PTA) of 3 cases (25.0%) were less than 40%, and serum albumin (Alb) of 7 cases (58.3%) decreased. Hepatomegaly was observed in 3 cases (25.0%), 1 case (8.3%) with splenomegalia and 3 cases (25.0%) with ascites. 8 cases (66.7%) were cured after anti-infection and liver protection therapy. 1 case (8.3%) was died and 3 cases (25.0%) were discharged. Conclusion  Liver dysfunction was generally found in the development process of Leptospirosis. Most of patients took a turn for the better in a short period of time. A minority of patients showed progressive development with liver sero-enzymes increased rapidly, and had serious jaundice and coagulation disorders. It should be distinguished with severe viral hepatitis. In severe cases, it even developed to liver failure and multiple organ function failure. The possibility of leptospirosis should be considered for patients with fever of unknown origin complicated with liver dysfunction.

Key words: Leptospirosis, Liver dysfunction, Clinical characteristic