Genetic branches, virulence genes, and protein functions of the mpox virus lineage B.1

doi:10.3969/j.issn.1672-2302.2024.01.001

Abstract

Abstract:

Mpox virus has been outbreak and prevalent in many countries worldwide since 2022. Compared with the previous mpox virus strains, the 2022 epidemic mpox strains had gained significantly enhanced transmission ability and host adaptability, and the mpox lineage B.1 strains had become the dominant strains in the global epidemic of mpox. In this paper, we reviewed the genetic branches, virulence genes and protein functions of the mpox B.1 strains, and annotated the protein functions of some of the gene products, with an attempt to provide reference for the scientific prevention and control of mpox epidemics.

Key words: Mpox virus, Lineage B.1 strain, Genetic branches, Virulence gene, Protein function

CLC Number:

R511

LIN Siyu, CHEN Fang, LUO Yusi, ZHANG Ke. Genetic branches, virulence genes, and protein functions of the mpox virus lineage B.1[J]. Journal of Tropical Diseases and Parasitology, 2024, 22(1): 1-6.

Figures/Tables 4

Table 1

Virulence genes, gene decoded proteins, and protein functions of MPXV

基因 / 编码蛋白	碱基数 / 氨基酸数	编码蛋白功能
A33R / 细胞外包膜特异性蛋白	429 / 142	促进病毒结合、融合和进入靶细胞^[21]
A32L / OPG157蛋白	234 / 77	编码OPG157蛋白，与牛痘病毒A30L蛋白同源，是致密病毒质与病毒包膜结合，形成成熟病毒颗粒必需的蛋白^[22]
A37R / A37R蛋白	531 / 176	编码A37R蛋白，与牛痘病毒A35R蛋白同源，A35R蛋白影响宿主抗原递呈细胞表面MHC Ⅱ类分子的表达^[23]，但目前A37R蛋白功能未知
A43R / 膜糖蛋白	594 / 197	识别抗原和免疫作用^[24]
A44R / A44R蛋白	225 / 74	蛋白功能尚不清楚，但A44R含有赖氨酸和天冬氨酸残基，是由盐键形成的稳定发夹折叠结构^[25]
A45L / 3-β-羟基-δ5-类固醇脱氢酶	1 041 / 346	调节激素合成和代谢^[6]
A47R / IL-1信号抑制器	723 / 240	抑制IL-1的作用^[6]
A51R/ OPG181蛋白	1 005 / 3 341	编码OPG181蛋白，与牛痘病毒A51同源，OPG181蛋白能与泛素结合，参与维持病毒蛋白稳定性和病毒复制^[26]
B4R / Schlafen样蛋白	1 512 / 503	抑制宿主细胞增殖，调控造血细胞，调节免疫应答等^[24]
B5R / 锚蛋白	1 686 / 561	参与宿主细胞黏附、信号传导以及mRNA转录等^[24]
B7R / 膜蛋白	531 / 176	识别抗原和免疫作用^[6]
B8R / 毒力因子，内质网驻留蛋白	549 / 182	参与蛋白质的折叠和组装等^[6]
B10R / 纤维瘤T4样蛋白	666 / 221	抑制淋巴细胞凋亡^[6]
B11R / 蛋白激酶样蛋白	849 / 282	参与细胞内信号传导^[6]
B12R / 丝氨酸蛋白酶抑制剂	1 035 / 344	抑制丝氨酸蛋白酶活性和IL-1β转化酶^[6]
B13R / IL-1结合蛋白抑制剂	450 / 149	抑制IL-1结合蛋白^[6]
B14R / IL-1β结合蛋白	981 / 326	阻止IL-1β与IL-1受体结合并激活与细胞凋亡相关信号^[6]
B16R / 干扰素-a/β（IFN-a/β）结合蛋白	1 059 / 352	调节细胞分化，参与宿主细胞增殖、先天性和适应性免疫^[6]
B17R / 锚蛋白	2 382 / 793	参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
B19R / 丝氨酸蛋白酶抑制剂	1 074 / 357	拮抗丝氨酸蛋白酶活性，参与凝血、纤溶和程序性细胞死亡等生物过程^[6]
B20R / 膜蛋白	573 / 190	识别抗原和免疫作用^[6]
B21R / 膜糖蛋白	5 640 / 1 879	识别抗原和免疫作用^[6]
C1L / 宿主范围因子，锚蛋白	855 / 284	调节靶细胞酶活性，抑制宿主细胞凋亡；参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
C2L / 丝氨酸蛋白酶抑制剂	1 128 / 375	拮抗丝氨酸蛋白酶活性，抑制宿主细胞融合^[6]
C4L / 磷脂酶D类蛋白	1 275 / 424	参与调控宿主细胞脂质代谢、信号传导、生物膜形成等生理生化过程^[6]
C5L / 磷脂酶B类蛋白	831 / 276	参与多种宿主细胞信号传导，调节细胞增殖分化^[6]
C6R / IL-1结合蛋白抑制剂	450 / 149	抑制IL-1结合蛋白功能^[6]
C7L / 细胞凋亡抑制剂	660 / 219	抑制宿主细胞凋亡^[6]
C9L / Kelch样蛋白	1 464 / 487	参与蛋白质泛素化修饰^[24]
C11L / 膜蛋白	1 032 / 343	识别抗原和免疫作用^[6]
D1L / 锚蛋白	1 314 / 437	参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
D3R / EGF样生长因子	429 / 142	调节细胞增殖和分化^[6]
D5R / 锌指蛋白，毒力因子	729 / 242	抑制紫外线诱导的细胞凋亡^[6]
D7L / 宿主范围因子，锚蛋白	1 983 / 660	调节靶细胞酶活性，抑制细胞凋亡；参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
D9L / 锚蛋白	1 893 / 630	参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
D10L / 宿主范围因子	453 / 150	调节靶细胞酶活性，抑制宿主细胞凋亡等^[6]
D11L / 核苷三磷酸水解酶	462 / 153	水解核苷三磷酸^[27]
D12L / Kelch样蛋白	621 / 206	参与蛋白质泛素化修饰^[24]
D13L / IL-1β拮抗剂	948 / 315	抑制IL-1作用，阻止IL-1与受体结合^[6]
D14L / 补体结合蛋白	651 / 216	猴痘补体酶抑制剂^[6]
H3L / IMV肝素结合表面膜蛋白	975 / 324	调节单核巨噬细胞功能，通过线粒体途径调节宿主细胞凋亡^[24]
J1L / CC趋化因子结合蛋白	741 / 246	启动CC趋化因子结合活性和CC趋化因子受体活性^[6]
J2L / TNF结合蛋白	1 047 / 348	抑制TNF活性，抑制其细胞毒活性和诱导IL-1产生^[6]
J3L / 锚蛋白	1 764 / 587	参与宿主细胞黏附、信号传导以及mRNA转录等^[6]
N1R / IL-1结合蛋白抑制剂	462 / 153	抑制IL-1结合蛋白^[28]
O1L / 锚蛋白	1 329 / 442	参与宿主细胞黏附、信号传导以及mRNA转录等^[16]
P2L / a-鹅膏菌素敏感性蛋白	534 / 177	RNA聚合酶Ⅱ特异性抑制剂^[5]

Table 1

Figure 1

Figure 2

Figure 3

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