Abstract:

【Abstract】 Objective  To analyze the screening results of infection with Toxoplasma gondii(TOX), rubella virus(RuV), cytomegalovirus(CMV) or herpes simplex virus(HSV)(TORCH) among women in early pregnancy in Huainan area, and to explore the clinical implications by TORCH test. Methods  Enzyme linked immunosorbent assay (ELISA) was performed to detect TORCH-IgM and TORCH-IgG antibodies in 4 832 pregnant women living in Huainan area. Results  Highest positive rate of HSV-IgM and IgG was found in the pregnant women received TORCH tests(P<0.05), and 48.84% (21/43) adverse pregnancy outcomes were associated with CMV. The difference was significant compared to adverse pregnancies caused by other virus(P<0.05). Abortion(65.12%, 28/43) appeared dominant in the incidence of adverse pregnancy, which was statistically different from other causative factors. Conclusion  Positive TORCH was detected in some women in early pregnancy in Huainan area, and TORCH infection is one of the important risk factors for adverse pregnancy outcomes. Therefore, TORCH test in the early stage of pregnancy or before pregnancy may have implications to improve local population quality of newborns.

Key words: TORCH infections, Adverse pregnancy, Early pregnancy, Huainan area