Abstract:

【Abstract】 Objective  To evaluate the therapeutic efficacy of film-coated praziquantel tablet in the treatment of patients infected with Schistosoma japonicum(S. japonicum) in areas with low endemicity. Methods  The dwellers aged 5 to 60 years from villages of low endemicity received stool examination for the S. japonicum infection using miracidium hatching test, and the positive cases were given etiological intervention with film-coated praziquantel tablet in dose of 60 or 40 mg/kg. Miracidium hatching test was performed after 6 weeks of medication to assess the therapeutic efficacy, and those that remained positive underwent the second treatment using the same protocol. All adverse events associated with praziquantel treatment were observed. Results  Of the 87 subjects, 43 had a history of once praziquantel treatment, and 44 a history of twice or over. Thirty-seven cases had moderate infection (EPG, 216-312), and 50 mild infection (EPG, 24-96). Re-examination with miracidium hatching test detected no S. japonicum miradium or egg following treatment with film-coated praziquantel tablet in dose of 60 mg/kg in 37 cases and 40 mg/kg in 50 cases. The incidence of adverse reactions was 17.24%. Conclusion  The therapeutic efficacy of film-coated praziquantel tablet remains sensitive to patients infected with S. japonicum in areas with low endemicity.

Key words: Schistosomiasis japonica, Film-coated praziquantel tablet, Sensitivity, Therapeutic efficacy