Abstract:

Objective To observe the plasma levels of copeptin, atrial natriuretic peptide(ANP), B-type natriuretic peptide (BNP) and n-terminal pro-brain natriuretic peptide (NT-proBNP)in patients with heart failure(HF), and explore the relationship with cardiac function. Methods 102 patients with heart failure were observed as HF group and 50 patients without heart failure were served as control group. Enzyme linked immunosorbent assay was adopted to detect the levels of CRP for all the patients. Fasting plasma glucose(FPG), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and so on were measured by automatic biochemical analyzer(PPI). Chemiluminescence method was adopted to detect the levels of Copeptin, ANP, BNP and NT-proBNP. Data was analyzed by SPSS13.0 software. Results Compared with control group, the levels of plasma Copeptin, ANP, BNP and NT-proBNP in HF group were significantly higher than that in control group (P<0.01), and the levels also increased with the classification of NYHA(P<0.01). The levels of Copeptin positively correlated with ANP, BNP and NT-proBNP. Conclusions The concentration of copeptin, BNP, NT-proBNP and ANP were increased with NYHA grading of cardiac function in patients with HF, which can be severed as a sensitive index on the diagnosis of heart failure and evaluation on cardiac function.

Key words: CT-pro-vasopressin (copeptin), Brain natriuretic peptide, Heart failure