基于CiteSpace的血吸虫循环抗原研究的文献计量分析

doi:10.20199/j.issn.1672-2302.2025.03.011

摘要/Abstract

摘要：

目的了解国内外血吸虫循环抗原的研究进展，为我国血吸虫病诊断提供参考。方法在中国知网（CNKI）和Web of Science（WoS）检索1990—2024年发表的血吸虫循环抗原相关文献，通过信息可视化分析软件CiteSpace对文献的作者、机构、关键词等进行可视化共现、聚类及突现分析。结果共获得中文文献264篇，英文文献498篇。中文文献发文量呈现先升后降趋势，英文文献总体呈上升趋势。中文文献中，娄文娴发文最多（14篇）；英文文献中，Deelder AM发文最多（108篇）。关键词分析显示，中文文献的主要聚类标签为“抗原”“红细胞”“吡喹酮”，突现强度最大的是“循环抗原”，突现持续时间最长的是“抗体”，突现词从“循环抗原”“红细胞”“疗效考核”逐渐向“金纳米棒”“联合检测”“血吸虫病”过渡。英文文献的主要聚类标签为“chemotherapy”（化学疗法）、“anodic antigen”（阳极抗原）和“intensity”（密度），突现强度最大的是“monoclonal antibody”（单克隆抗体），突现持续时间最长的为“individuals”（个体），突现词从“monoclonal antibody”“individuals”“neglected tropical diseases”（被忽视的热带病）逐步向“prevalence”（患病率）和“Schistosoma mansoni”（曼氏血吸虫）等过渡。结论目前我国学者对血吸虫循环抗原的研究较少，建议国内加强对血吸虫循环抗原的研究，加强多学科、多机构协同攻关，为我国实现血吸虫病消除目标提供技术支撑。

关键词: 血吸虫, 循环抗原, 研究进展, 文献计量学, CiteSpace

Abstract:

Objective To understand the research progress of schistosome circulating antigen studies globally and domestically for reference for schistosomiasis diagnosis in China. Methods Literature on schistosome circulating antigen published between 1990 and 2024 was retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WoS). CiteSpace was used for visual co-occurrence, clustering and burst analysis of authors, institutions and keywords. Results In total, 264 Chinese and 498 English articles were retrieved. Chinese publications showed an initial increase followed by a decline, whereas English literature demonstrated a steady upward trend. In the Chinese publications, Lou Wenxian was the most prolific author (14 articles), and Deelder AM contributed 108 articles in English literature. Keyword analysis revealed that Chinese research clusters focused on “antigen”, “erythrocyte”, and “praziquantel” with the strongest burst term being “circulating antigen” and the longest-lasting burst term being “antibody”. Burst terms shifted from “circulating antigen”, “erythrocyte”, and “therapeutic efficacy evaluation” to “gold nanorods”, “combined detection”, and “schistosomiasis”. For English publications, major clusters included “chemotherapy”, “anodic antigen”, and “intensity”, with the highest burst intensity for “monoclonal antibody” and the longest burst duration for “individuals”. Burst terms transitioned from “monoclonal antibodies”, “individuals”, and “neglected tropical diseases” to “prevalence” and “Schistosoma mansoni”. Conclusion Current research on schistosome circulating antigen by Chinese scholars remains limited, for which we recommend that interdisciplinary and multi-institutional collaboration should be strengthened to advance schistosome circulating antigen studies, thereby supporting China’s goal of schistosomiasis elimination.

Key words: Schistosome, Circulating antigen, Research progress, Bibliometrics, CiteSpace

中图分类号:

R383.2+4

唐琦, 吕超, 周新杰, 冯婷, 许静, 秦志强. 基于CiteSpace的血吸虫循环抗原研究的文献计量分析[J]. 热带病与寄生虫学, 2025, 23(3): 189-194.

TANG Qi, LÜ Chao, ZHOU Xinjie, FENG Ting, XU Jing, QIN Zhiqiang. Bibliometric analysis of schistosome circulating antigen based on CiteSpace[J]. Journal of Tropical Diseases and Parasitology, 2025, 23(3): 189-194.

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