茶树油治疗蠕形螨性眼病的研究进展

doi:10.3969/j.issn.1672-2302.2023.01.011

摘要/Abstract

摘要：

眼部蠕形螨感染可造成患者眼表不适，引起多种眼部疾病，近年来发病率呈上升趋势。茶树油及其衍生物不仅有显著的杀螨效果，还具有抗菌、抗炎活性，是治疗蠕形螨性眼病的常用制剂。目前茶树油相关制剂品种多样，其安全性和最佳使用方法等均未有充分的研究证明。本文对茶树油治疗蠕形螨性眼病的机制、使用方法、安全性和疗效等方面进行综述，以期为临床治疗蠕形螨性眼病提供参考。

关键词: 茶树油, 蠕形螨, 眼病, 治疗, 研究进展

Abstract:

Ocular Demodex infection can cause discomfort of the ocular surface and a variety of ocular conditions, and the incidence has been increasing in recent years. Tea tree oil and its derivatives not only have significant acaricidal effect, but also have antibacterial and anti-inflammatory activities, and are commonly used in the treatment of Demodex eye disease. Currently, various kinds of preparations from tea tree oil are available, yet the safety and optimal use of the related extract have not been fully clarified. This paper reviewed the mechanism, application, safety and efficacy of tea tree oil in the treatment of Demodex eye conditions, with an attempt to provide reference for clinical use of this extract for ocular Demodex infestation.

Key words: Tea tree oil, Demodex, Eye disease, Treatment, Research progress

中图分类号:

R384.4

郑馨武, 谢思健, 谢文军. 茶树油治疗蠕形螨性眼病的研究进展[J]. 热带病与寄生虫学, 2023, 21(1): 57-61.

ZHENG Xin-wu, XIE Si-jian, XIE Wen-jun. Research progress of tea tree oil in the treatment of eye diseases caused by Demodex[J]. Journal of Tropical Diseases and Parasitology, 2023, 21(1): 57-61.

参考文献 50

[1]	Luo XH, Li J, Chen C, et al. Ocular demodicosis as a potential cause of ocular surface inflammation[J]. Cornea, 2017, 36(Suppl 1):S9-S14. doi: 10.1097/ICO.0000000000001361 URL
[2]	Nicholls SG, Oakley CL, Tan A, et al. Demodex species in human ocular disease: new clinicopathological aspects[J]. Int Ophthalmol, 2017, 37(1):303-312. doi: 10.1007/s10792-016-0249-9 pmid: 27160273
[3]	Jones L, Downie LE, Korb D, et al. TFOS DEWS II management and therapy report[J]. Ocul Surf, 2017, 15(3):575-628. doi: S1542-0124(17)30114-3 pmid: 28736343
[4]	Martínez-Pulgarín DF, Ávila MY, Rodríguez-Morales AJ. Interventions for Demodex blepharitis and their effectiveness: a systematic review and meta-analysis[J]. Contact Lens Anterior Eye, 2021, 44(6):101453. doi: 10.1016/j.clae.2021.101453 URL
[5]	Lam NSK, Long XX, Griffin RC, et al. Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?[J]. Parasitology, 2018, 145(12):1510-1520. doi: 10.1017/S0031182018000495 URL
[6]	Hammer KA, Carson CF, Riley TV, et al. A review of the toxicity of Melaleuca alternifolia (tea tree) oil[J]. Food Chem Toxicol, 2006, 44(5):616-625. pmid: 16243420
[7]	Borotová P, Galovičová L, Vukovic NL, et al. Chemical and biological characterization of Melaleuca alternifolia essential oil[J]. Plants (Basel), 2022, 11(4):558.
[8]	Akçınar UG, Ünal E, Akpınar M. Demodex spp. infestation associated with treatment-resistant chalazia and folliculitis[J]. Turkiye Parazitol Derg, 2016, 40(4):208-210. doi: 10.5152/tpd. URL
[9]	Liang LY, Liu Y, Ding XH, et al. Significant correlation between meibomian gland dysfunction and keratitis in young patients with Demodex brevis infestation[J]. Br J Ophthalmol, 2018, 102(8):1098-1102. doi: 10.1136/bjophthalmol-2017-310302 URL
[10]	Gazi U, Gureser AS, Oztekin A, et al. Skin-homing T-cell responses associated with Demodex infestation and rosacea[J]. Parasite Immunol, 2019, 41(8):e12658.
[11]	Yan Y, Yao QK, Lu Y, et al. Association between Demodex infestation and ocular surface microbiota in patients with Demodex blepharitis[J]. Front Med (Lausanne), 2020, 7:592759.
[12]	亚洲干眼协会中国分会, 海峡两岸医药交流协会眼科专业委员会眼表与泪液病学组. 我国蠕形螨睑缘炎诊断和治疗专家共识(2018年)[J]. 中华眼科杂志, 2018, 54(7):491-495.
[13]	Tighe S, Gao YY, Tseng SCG. Terpinen-4-ol is the most active ingredient of tea tree oil to kill Demodex mites[J]. Transl Vis Sci Technol, 2013, 2(7):2.
[14]	Gao YY, Di Pascuale MA, Li W, et al. In vitro and in vivo killing of ocular Demodex by tea tree oil[J]. Br J Ophthalmol, 2005, 89(11):1468-1473. doi: 10.1136/bjo.2005.072363 URL
[15]	Yurekli A, Botsali A. The comparative in vitro killing activity of tea tree oil versus permethrin on Demodex folliculorum of rosacea patients[J]. J Cosmet Dermatol, 2022, 21(5):2268-2272. doi: 10.1111/jocd.v21.5 URL
[16]	Heczko J, Schell C, Pansick A, et al. Evaluation of a novel treatment, selenium disulfide, in killing Demodex folliculorum in vitro[J/OL]. Can J Ophthalmol. [2022-08-14]. https://pubmed.ncbi.nlm.nih.gov/35594910/.
[17]	Kabat AG. In vitro demodicidal activity of commercial lid hygiene products[J]. Clin Ophthalmol, 2019, 13:1493-1497. doi: 10.2147/OPTH URL
[18]	陈媛, 郝小波, 廖原. 茶树油眼部清洁湿巾缓解蠕形螨感染性睑缘炎的临床研究[J]. 中医眼耳鼻喉杂志, 2022, 12(1):18-21.
[19]	Bulut A, Tanriverdi C. Anti-Demodex effect of commercial eyelid hygiene products[J]. Semin Ophthalmol, 2021, 36(8):719-722. doi: 10.1080/08820538.2021.1897859 URL
[20]	Navel V, Mulliez A, Benoist d'Azy C, et al. Efficacy of treatments for Demodex blepharitis: a systematic review and meta-analysis[J]. Ocul Surf, 2019, 17(4):655-669. doi: 10.1016/j.jtos.2019.06.004 URL
[21]	Nogueira MM, Aquino SG, et al. Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages[J]. Inflamm Res, 2014, 63(9):769-778. doi: 10.1007/s00011-014-0749-x pmid: 24947163
[22]	Ergun SB, Saribas GS, Yarayici S, et al. Comparison of efficacy and safety of two tea tree oil-based formulations in patients with chronic blepharitis: a double-blinded randomized clinical trial[J]. Ocul Immunol Inflamm, 2020, 28(6):888-897. doi: 10.1080/09273948.2019.1644349 pmid: 31429629
[23]	Shi C, Zhang XW, Guo N. The antimicrobial activities and action-mechanism of tea tree oil against food-borne bacteria in fresh cucumber juice[J]. Microb Pathog, 2018, 125:262-271. doi: 10.1016/j.micpath.2018.09.036 URL
[24]	Cheung IMY, Xue AL, Kim A, et al. In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers[J]. Cont Lens Anterior Eye, 2018, 41(6):513-517. doi: 10.1016/j.clae.2018.08.003 URL
[25]	Su CW, Tighe S, Sheha H, et al. Safety and efficacy of 4-terpineol against microorganisms associated with blepharitis and common ocular diseases[J]. BMJ Open Ophthalmol, 2018, 3(1):e000094. doi: 10.1136/bmjophth-2017-000094 URL
[26]	Karakurt Y, Zeytun E. Evaluation of the efficacy of tea tree oil on the density of Demodex mites (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis[J]. J Parasitol, 2018, 104(5):473-478. doi: 10.1645/18-46 pmid: 30016200
[27]	高莹莹, 黄丽娟, 董雪青, 等. 5%茶树油眼膏治疗蠕形螨相关鳞屑性睑缘炎[J]. 中华眼视光学与视觉科学杂志, 2016, 18(1):50-53.
[28]	钟琼蕾, 张开颜, 陈颖颖, 等. 热带地区螨虫相关性眼病的治疗方法探讨[J]. 中国热带医学, 2021, 21(9):912-916.
[29]	Jacobi C, Doan S, Pavel V, et al. Different approach to manage Demodex blepharitis-initial and maintenance treatment[J]. Curr Eye Res, 2022, 47(3):352-360. doi: 10.1080/02713683.2021.1978099 URL
[30]	Tharmarajah B, Coroneo MT. Corneal effects of tea tree oil[J]. Cornea, 2021, 40(10):1363-1364. doi: 10.1097/ICO.0000000000002776 pmid: 34074891
[31]	Koo H, Kim TH, Kim KW, et al. Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis[J]. J Korean Med Sci, 2012, 27(12):1574-1579. doi: 10.3346/jkms.2012.27.12.1574 URL
[32]	艾丽珍, 余兰慧, 赖瑶, 等. 不同浓度茶树精油治疗蠕形螨睑缘炎的有效性及安全性[J]. 国际眼科杂志, 2022, 22(1):104-108.
[33]	Homeyer DC, Sanchez CJ, Mende K, et al. In vitro activity of Melaleuca alternifolia (tea tree) oil on filamentous fungi and toxicity to human cells[J]. Med Mycol, 2015, 53(3):285-294. doi: 10.1093/mmy/myu072 pmid: 25631479
[34]	Chen D, Wang JY, Sullivan DA, et al. Effects of terpinen-4-ol on meibomian gland epithelial cells in vitro[J]. Cornea, 2020, 39(12):1541-1546. doi: 10.1097/ICO.0000000000002506 URL
[35]	Alver O, Kıvanç SA, Akova Budak B, et al. A clinical scoring system for diagnosis of ocular demodicosis[J]. Med Sci Monit, 2017, 23:5862-5869. doi: 10.12659/MSM.907824 URL
[36]	Murphy O, O'Dwyer V, Lloyd-McKernan A. The efficacy of tea tree face wash, 1, 2-Octanediol and microblepharoexfoliation in treating Demodex folliculorum blepharitis[J]. Contact Lens Anterior Eye, 2018, 41(1):77-82. doi: 10.1016/j.clae.2017.10.012 URL
[37]	Evren Kemer Ö, Karaca EE, Özek D. Efficacy of cyclic therapy with terpinen-4-ol in Demodex blepharitis: is treatment possible by considering Demodex's life cycle?[J]. Eur J Ophthalmol, 2021, 31(3):1361-1366. doi: 10.1177/1120672120919085 URL
[38]	López-Ponce D, Zuazo F, Cartes C, et al. High prevalence of Demodex spp. infestation among patients with posterior blepharitis: correlation with age and cylindrical dandruff[J]. Arch Soc Esp Oftalmol, 2017, 92(9):412-418. doi: S0365-6691(17)30022-9 pmid: 28552438
[39]	Mohammad-Rabei H, Arabi A, Shahraki T, et al. Role of blepharoexfoliation in Demodex blepharitis: a randomized comparative study[J]. Cornea, 2023, 42(1):44-51. doi: 10.1097/ICO.0000000000003046 URL
[40]	王玉倩, 李颖, 戴鹏飞, 等. 茶树油眼贴联合睑缘深度清洁治疗蠕形螨睑缘炎的临床疗效[J]. 国际眼科杂志, 2020, 20(10):1791-1796.
[41]	陈石. 妥布霉素地塞米松眼膏联合茶树油治疗蠕形螨睑缘炎的观察[J]. 中国疗养医学, 2018, 27(9):973-975.
[42]	柯兰, 杨燕宁, 黄林英, 等. 妥布霉素地塞米松眼膏联合茶树油治疗蠕形螨性睑缘炎的观察[J]. 中华眼视光学与视觉科学杂志, 2017, 19(3):176-181.
[43]	吴越, 郭晓红, 桂孟芳, 等. 老年睑板腺功能障碍蠕形螨感染率及茶树精油联合氟米龙的疗效[J]. 国际眼科杂志, 2019, 19(9):1566-1569.
[44]	Ávila MY, Martínez-Pulgarín DF, Rizo Madrid C. Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp. : a randomized clinical trial[J]. Contact Lens Anterior Eye, 2021, 44(3):101326. doi: 10.1016/j.clae.2020.04.011 URL
[45]	胡煜. 荼树油与甲硝唑在蠕形螨睑缘炎中的应用[J]. 基层医学论坛, 2017, 21(23):3165-3166.
[46]	干眼强脉冲光临床应用专家共识专家组, 中国康复医学会视觉康复专委会干眼康复专业组. 强脉冲光治疗睑板腺功能障碍及其相关干眼专家共识(2022)[J]. 中华实验眼科杂志, 2022, 40(2):97-103.
[47]	Wang PR, Zhang LL, Shi L, et al. Latent Demodex infection contributes to intense pulsed light aggravated rosacea: cases serial[J]. J Cosmet Laser Ther, 2019, 21(3):163-165. doi: 10.1080/14764172.2018.1502448 URL
[48]	方颉, 林志荣, 吴护平. 强脉冲激光治疗蠕形螨性睑缘炎的临床观察[J]. 深圳中西医结合杂志, 2021, 31(24):86-89.
[49]	吕学锋, 沈锦霞, 陈雅琼. 优化强脉冲光联合茶树精油眼贴治疗蠕形螨性睑缘炎[J]. 国际眼科杂志, 2021, 21(1):178-181.
[50]	Savla K, Le JT, Pucker AD. Tea tree oil for Demodex blepharitis[J]. Cochrane Database Syst Rev, 2020, 6(6):CD013333.