热带病与寄生虫学

热带病与寄生虫学 ›› 2022, Vol. 20 ›› Issue (4): 228-234.

• 综述 • 上一篇    下一篇

医学蠕虫感染宿主的肠道微生物组学研究进展

胡玥，詹荣健，吕志跃   

  1. 中山大学中山医学院寄生虫学教研室，广东 广州 510080

  • 收稿日期:2022-03-22 出版日期:2022-08-20 发布日期:2022-08-31
  • 作者简介:胡玥，女，博士，助理研究员，研究方向：寄生虫感染与免疫。E-mail: huyue73@mail.sysu.edu.cn
  • 基金资助:
    国家寄生虫资源库 （NPRC-2019-194-30）；国家自然科学基金项目（82072303）；海南省院士创新平台科研专项（YSPTZX202133）

Advances in the study of medical helminth infection on host gut microbiome

HU Yue, ZHAN Rong-jian, LÜ Zhi-yue   

  1. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
  • Received:2022-03-22 Online:2022-08-20 Published:2022-08-31

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摘要： 寄生于哺乳动物和人类肠腔内的医学蠕虫与肠道微生物相互作用、相互调节，改变宿主肠道微环境的稳态与平衡，并影响疾病的发生、发展和预后。本文从肠道微生态、免疫反应及代谢反应等方面就医学蠕虫感染宿主治疗前后肠道微生物的研究进行综述，旨在为肠道菌群在寄生虫病的致病机制研究以及诊断治疗等方面提供新视角和理论依据。

关键词: 医学蠕虫, 肠道微生物, 宿主, 组学

Abstract: Medical helminth parasitizing in the intestines of mammals and humans can interact with and regulate gut microorganisms, alter the homeostasis and balance of host's intestinal microenvironment, and affect the development, progression and prognosis of diseases. In this paper, the study of medical helminth infection on host gut microbiota before and after treatment were summarized from the aspects of intestinal microecology, immune response and metabolic reaction, in order to provide a new perspective and theoretical basis of intestinal flora on the pathogenesis, diagnosis and treatment of parasitic diseases.

Key words: Medical helminth, Gut microbiota, Host, Omics

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