热带病与寄生虫学

热带病与寄生虫学 ›› 2021, Vol. 19 ›› Issue (5): 292-.

• 综述 • 上一篇    下一篇

我国乙型脑炎病毒优势基因型转换及其风险和对策

苑中芬1,狄荻2,李宗杰2,魏建超2
  

  1. 1. 莒县疾病预防控制中心,山东 日照 276599; 2. 中国农业科学院上海兽医研究所
  • 出版日期:2021-10-20 发布日期:2021-11-03
  • 通信作者: 李宗杰,E-mail:lizongjie@ shvri. ac. cn;魏建超,E-mail:jianchaowei@ shvri. ac. cn
  • 作者简介:苑中芬,女,本科,主管医师,研究方向:疾病控制和免疫规划工作。 E-mail:zhongfenyuan0124@ 163. com
  • 基金资助:
    国家国际科技合作专项(2014DFE30140);上海科委农业重点科技攻关项目(17391901600)

Research progress in the shifting trend of dominant genotype of Japanese encephalitis virus and its control strategies in China

YUAN Zhong-fen1,DI Di2,LI Zong-jie2,WEI Jian-chao2   

  1. 1. Disease Prevention and Control Center of Juxian County,Rizhao 276599,Shandong Province,China; 2. Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Science (CAAS)
  • Online:2021-10-20 Published:2021-11-03

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摘要： 乙型脑炎是由乙型脑炎病毒引起的人畜共患病,在自然界中主要是通过蚊虫叮咬进行传播,能够引起人的中枢神经系统损伤和猪的繁殖障碍等疾病,对公共卫生安全造成了严重威胁。 由于乙型脑炎病毒在水禽宿主中的适应性差异,导致了病毒优势基因型由 GⅢ型逐渐向 GⅠ型转变。 乙型脑炎病毒优势基因型的转换和流行范围的扩大给疾病防控带来了新挑战,本文对我国乙型脑炎病毒优势基因型转换及其风险和对策进行了综述。

关键词: 乙型脑炎, 乙型脑炎病毒, 基因型转换, 风险分析, 防控策略

Abstract: Japanese encephalitis is a zoonosis caused by Japanese encephalitis virus. It is mainly transmitted through bites of mosquitoes in natural environment,causing diseases such as injury of human central nervous system and disorders in pig breeding as well as leading to serious threat to the public health and safety. Currently,the dominant genotype of Japanese encephalitis virus is shifting from GⅢ to GIⅠ because of the adaptability difference of the virus in waterfowl hosts. Transformation of the dominant Japanese encephalitis virus genotypes and extension of epidemic scope have brought new challenges to disease prevention and control. This paper reviews the research progress in the shifting trend of dominant genotype of Japanese encephalitis virus and its control strategies in China.

Key words: Japanese encephalitis, Japanese encephalitis virus, Risk analysis, Genotype shift, Control strategies

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