热带病与寄生虫学

热带病与寄生虫学 ›› 2021, Vol. 19 ›› Issue (2): 70-73.

• 论著 • 上一篇    下一篇

某肿瘤医院儿童血液病患者 TORCH 感染状况研究

张倩,陈少华,孙永梅,陈兆武,李明
  

  1. 中国科学技术大学附属第一医院(安徽省立医院)检验科,安徽 合肥 233004
  • 出版日期:2021-04-20 发布日期:2021-04-22
  • 通信作者: 李明,E-mail:362121566@ qq. com
  • 作者简介:张倩,女,博士,医师,研究方向:感染免疫。 E-mail:zhangqian_7116@ 163. com
  • 基金资助:
    中央高校基本科研业务费专项资金资助(WK9110000026)

Prevalence of TORCH infection in hospitalized children with hematological diseases in a cancer hospital 

ZHANG Qian,CHEN Shao-hua,SUN Yong-mei,CHEN Zhao-wu,LI Ming    

  1. Department of Clinical laboratory,The First Affiliated Hospital of University of Science and Technology of China,Hefei 233004,Anhui Province,China
  • Online:2021-04-20 Published:2021-04-22

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摘要： 目的 研究中国科学技术大学附属第一医院西区(安徽省肿瘤医院)儿童血液病患者 TORCH 感染的状况。方法 选取 2015 年 11 月—2019 年 7 月在该院儿血科住院的 354 例患儿为研究对象,采用化学发光免疫测定仪检测患儿血 TORCH 的 IgG、IgM 抗体,分析 354 例患儿 TORCH 感染模式、年龄和疾病分布状况。 结果 弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)IgM 阳性率分别为 0. 6%、4. 2%和 7. 3%;TOX、RV、CMV、单纯疱疹病毒(HSV-Ⅰ、HSV-Ⅱ)的 IgG 阳性率分别为 21. 2%、88. 1%、91. 2%、49. 2%、15. 8%。 合并感染 1 例,为 CMV 和 RV 合并感染。 不同年龄段儿童 RV-IgM、CMV-IgM、RV-IgG、HSV-Ⅰ-IgG 和 HSV-Ⅱ-IgG 阳性率差异有统计学意义。 卡方趋势检验结果显示,RV-IgM、CMV-IgM 和 HSV-Ⅱ-IgG 阳性率随着患儿年龄增加而下降,RV-IgG 和 HSV-Ⅰ-IgG 阳性率随患儿年龄增加而上升。 不同疾病类型的患儿,其 TOX-IgG、HSV-Ⅰ-IgG、HSV-Ⅱ-IgG 阳性率差异有统计学意义。 结论 对血液病患儿开展 TORCH 血清学检测,可明确其感染类型和既往感染情况,为血液病的诊断和治疗提供帮助。

关键词: TORCH 感染, 儿童血液病, 刚地弓形虫, 风疹病毒, 巨细胞病毒, 单纯疱疹病毒

Abstract: Objective To investigate the status of TORCH infection in children with hematological diseases in the First Affiliated Hospital of USTC (Western District),Anhui Provincial Cancer Hospital. Methods 354 children treated in the Department of Pediatric Hematology of our hospital were included from November 2015 to July 2019. Blood samples were obtained from all children, and detected for the TORCH-IgG and IgM using chemiluminescence immunoassay. Then the TORCH infection pattern, age distribution and disease types were analyzed in the 354 patients. Results TORCH test showed that the positive rate was 0. 6%,4. 2% and 7. 3% for Toxoplasma-immunoglobulin M (TOX-IgM),rubella virus-IgM (RV-IgM) and cytomegalovirus-IgM (CMV-IgM),and 21. 2%,88. 1%,91. 2%,49. 2% and 15. 8% for TOX-IgG,RV-IgG, CMV-IgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG,respectively. Co-infection of CMV+RV occurred in one child. The infection rate of RV-IgM( +),CMV-IgM( +), RV-IgG( +),HSV-Ⅰ-IgG( +) or HSV-Ⅱ-IgG( +) was significantly different in different age group. Chi square trend test showed that the positive rates of RV-IgM,CMV-IgM and HSV-Ⅱ-IgG decreased with the age of children,while the positive rates of RV-IgG and HSV-Ⅰ-IgG increased with the age of children. The positive rate of TOXIgG,HSV-Ⅰ-IgG and HSV-Ⅱ-IgG was significantly different in children with diverse type of infection. Conclusion TORCH-IgG and IgM detection in children with hematological diseases can identify the type of infection and previous infection,and provide help for the diagnosis and treatment of hematological diseases.

Key words: TORCH infection, Childhood hematopathy, Toxoplasma gondii, Rubella, Cytomegalovirus, Herpes simplex virus

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