Abstract: Hemorrhagic fever with renal syndrome ( HFRS) is a natural focus disease originated from animal infection. The pathogenesis of HFRS is controlled by many factors, in which the pathogenic immune plays a major role. Studies demonstrated that HFRS was closely connected with human leukocyte antigen(HLA) gene polymorphism, and the genetic correlation and course severity of HFRS were affected by HLA gene polymorphism at a certain level. This paper aims at reviewing the research progress in HFRS and HLA gene polymorphism in order to provide a scientific basis for early clinical screening and diagnosis of HFRS as well as assessment of the disease risks.

Key words: Human leukocyte antigen, Polymorphism, Hemorrhagic fever with renal syndrome, Correlation, Progress