热带病与寄生虫学

热带病与寄生虫学 ›› 2021, Vol. 19 ›› Issue (1): 47-51.

• 综述 • 上一篇    下一篇

AMPK信号通路及其在感染性疾病中的研究进展

颜明智1,2,赵军3,刘辉1,毕晓娟1,吕国栋1,2   

  1. 1.新疆医科大学第一附属医院临床医学研究院省部共建中亚高发病成因与防治国家重点实验室,新疆乌鲁木齐830054;2.新疆医科大学药学院;3.新疆医科大学第一附属医院药学部临床药学科

  • 出版日期:2021-02-20 发布日期:2021-02-04
  • 通信作者: 吕国栋,E-mail lgd_xj@qq com
  • 作者简介:颜明智,男,硕士在读,研究方向:新药研发。E-mail 451417137@qq com
  • 基金资助:
    国家自然科学基金项目( 82060373,81760369);省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2017-Y1);中国博士后科学基金面上项目(2019M653802)

AMPK signaling pathway and its research progress in infectious disease

YAN Ming-zhi1 2 ,ZHAO Jun3, LIU Hui1 ,BI Xiao-juan1 ,LÜ Guo-dong1 2   

  1. 1 State Key Laboratory of Pathogenesis Prevention and Treatment of Central Asian High Incidence Diseases Clinical Medical Research Institute The First Affiliated Hospital of Xinjiang Medical University ,Urumqi 830054 ,Xinjiang Uygur Autonomous Region ,China;2 College of Pharmacy Xinjiang Medical University;3 Department of Clinical Pharmacy The First Affiliated Hospital of Xinjiang Medical University
  • Online:2021-02-20 Published:2021-02-04

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摘要： 腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种AMP依赖性的蛋白激酶,负责调节细胞能量的合成与分解,是细胞生长、繁殖和自噬的关键调节剂。AMPK及其信号通路在病毒、细菌和寄生虫等感染中发挥了重要作用,有望成为一种药物新靶点。本文将对近年来AMPK信号通路在感染性疾病中的研究展开综述。

关键词: 腺苷酸活化蛋白激酶信号通路, 能量代谢, 感染性疾病, 病原体, 药物靶点

Abstract: AMP-activated protein kinase (AMPK),an AMP-dependent protein kinase responsible for regulating the synthesis and catabolism of cellular energy,is a key regulator for cell growth,reproduction and autophagy.AMPK and its signaling pathway play an important role in viral,bacterial and parasitic infections and are expected to be a new drug target.In this paper,we reviewed the recent research on AMPK signaling pathway in infectious diseases.

Key words: AMPK signaling pathway, Energy metabolism, Infectious diseases , Pathogens , Drug target

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