IL-33/ST2信号通路在肝脏疾病中的作用及其机制的研究进展

热带病与寄生虫学 ›› 2021, Vol. 19 ›› Issue (1): 41-46.

IL-33/ST2信号通路在肝脏疾病中的作用及其机制的研究进展

白杨,雷家慧,关飞

华中科技大学同济医学院基础医学院病原生物学系,湖北武汉430030

出版日期:2021-02-20 发布日期:2021-02-04
通信作者: 关飞,E-mail guanfei@hust edu cn
作者简介:白杨,女,硕士在读,研究方向:寄生虫感染免疫。E-mail baiyanghust@163 com
基金资助:
中央高校基本科研业务费资助(HUST:2016YXMS199);国家自然基金项目(81772220)

Research progress on the role and mechanisms of IL-33 ST2 signaling pathway in liver disease#br#

BAI Yang, LEI Jia-hui ,GUAN Fei

Department of Pathogen Biology School of Basic Medicine Tongji Medical College ,Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China

Online:2021-02-20 Published:2021-02-04

摘要/Abstract

摘要： 本文主要介绍了肝脏疾病中IL-33/ST2信号通路的作用及机制的研究现况。IL-33是机体主要的免疫调节因子,通过与多种免疫细胞(如Th2、Treg、ILC2、DC等)表面的受体ST2结合发挥效应。在脂肪肝、慢性肝炎、肝纤维化、肝硬化以及肝癌等肝脏疾病中,IL-33与其受体ST2的表达水平均升高。IL-33/ST2信号通路通过活化多种免疫细胞,促进其分泌相应的细胞因子(IL-5、IL-13、IL-10等),进而在宿主免疫防御、组织修复及免疫稳态调节等方面发挥至关重要的作用。

关键词: 白介素33, ST2, 免疫调节, 肝脏疾病

Abstract: This paper describes the advance in research of the role and mechanisms of IL-33/ST2 signaling pathway. IL-33 represents a major immunoregulatory factor and generates pleiotropic effects on various immune cells (e.g, Th2,Treg,ILC2,DC) via binding with the surface receptor ST2.Recent studies demonstrated up-regulated expression of IL-33 and its ST2 receptor in liver diseases,such as fatty liver,chronic hepatitis,liver fibrosis and cirrhosis as well as liver cancer.IL-33/ST2 signaling pathway can promote secretion of cytokines (IL-5,IL-13,IL-10,etc.) by activating a variety of immune cells,thus playing a pivotal role in host immune defense,tissue repair and maintenance of immune homeostasis.

Key words: Interleukin-33 , ST2 , Immune regulation, Liver diseases

中图分类号:

R575

白杨, 雷家慧, 关飞. IL-33/ST2信号通路在肝脏疾病中的作用及其机制的研究进展[J]. 热带病与寄生虫学, 2021, 19(1): 41-46.

BAI Yang, LEI Jia-hui , GUAN Fei. Research progress on the role and mechanisms of IL-33 ST2 signaling pathway in liver disease#br#[J]. Journal of Tropical Diseases and Parasitology, 2021, 19(1): 41-46.