热带病与寄生虫学

热带病与寄生虫学 ›› 2022, Vol. 20 ›› Issue (2): 99-102.

• 实验研究 • 上一篇    下一篇

50%氯硝柳胺乙醇胺盐可湿粉剂冬季浸杀钉螺效果观察

汪为春1，詹惕1，范泽涵1，项可霞1，朱应富1，段永梅1，操治国2   

  1. 1. 马鞍山市疾病预防控制中心，安徽 马鞍山 243000
    2. 安徽省血吸虫病防治研究所
  • 收稿日期:2021-05-06 出版日期:2022-04-20 发布日期:2022-04-29
  • 通信作者: 操治国，E-mail：ahzhiguo@126.com
  • 作者简介:汪为春，男，本科，副主任医师，研究方向：血吸虫病防控。E-mail：33966022@qq.com
  • 基金资助:
    安徽省重点研究与开发计划（202104j07020001）；安徽省创新创业领军人才特殊支持计划经费资助；马鞍山市“公共卫生与预防医学”科研课题（马预字﹝2020﹞2号）

Observation on the molluscicidal effect of 50% wettable powder of niclosamide ethanolamine salt on Oncomelania hupensis by immersion method in winter#br#

WANG Wei-chun1, ZHAN Ti1, FAN Ze-han1, XIANG Ke-xia1, ZHU Ying-fu1, DUAN Yong-mei1, CAO Zhi-guo2   

  1. 1. Maanshan Center for Disease Control and Prevention, Maanshan 243000, Anhui Province, China;
    2. Anhui Provincial Institute of Schistosomiasis Control
  • Received:2021-05-06 Online:2022-04-20 Published:2022-04-29

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摘要： 目的 在冬季对50%氯硝柳胺乙醇胺盐可湿粉剂（wettable powder of niclosamide ethanolamine salt，WPNES）的浸杀灭螺效果进行观察，以探索冬季开展药物灭螺工作的可行性。方法 于冬季设置室外观察组（-2～10 ℃）和室内对照组（19～25 ℃）观察50%WPNES浸杀灭螺效果，2组均包含6个浓度的施药组（按照有效含量从高到低分别为1.000 0、0.500 0、0.250 0、0.125 0、0.062 5、0.031 3 mg/L）和1个脱氯水空白对照组。观察并计算各组24、48和72 h的钉螺死亡率和半数致死浓度（LC50）。结果 室外观察组各浓度浸杀24、48和72 h钉螺死亡率均低于室内对照组，但随着时间延长，两组LC50差距逐渐缩小。1.000 0 mg/L50%WPNES浸杀72 h时，室外观察组钉螺死亡率达到100.00%，LC50为0.153 3 mg/L，符合中华人民共和国农业行业标准《农药登记用杀钉螺剂药效试验方法和评价》（NY/T 1617—2008）要求。结论 冬季低温条件下50%WPNES浸杀灭螺具有可行性，但其现场条件下的灭螺效果尚需进一步验证。

关键词: 氯硝柳胺, 浸杀法, 冬季, 钉螺

Abstract: Objective To observe the efficacy of 50% wettable powder of niclosamide ethanolamine salt(WPNES) in killing Oncomelania hupensis by immersion method for the feasibility in snail control in cold seasons. Methods Outdoor observational group (-2-10°C) and indoor control group (19-25°C) were set to observe the effect of 50% WPNEs on snail killing by immersion technique in winter. The two groups were composed of 6 subgroups of concentrations by effective agent use(ranging from 1.000 0 mg/L, 0.500 0 mg/L, 0.250 0 mg/L, 0.125 0 mg/L, 0.062 5 mg/L to 0.031 3 mg/L) and a blank control group treated by dechlorination water. Mortality and LC50 of snails at 24, 48 and 72 hours in each group were observed and calculated. Results Mortality rates of snails exposed to various concentrations for 24, 48 and 72 h were lower in the outdoor observational group than in the indoor control group, yet LC50 tended to be approximate between the two groups with prolonged exposure time. By the exposure time at 72 h, the mortality rate of snail in outdoor observational group reached 100.00% at the concentration of 1.000 0 mg/L50 %WPNES, and the LC50 was 0.153 3 mg/L. This molluscicidal effect had met the requirements specified in NY/T 1617—2008 Efficacy test methods and evaluation of molluscicide for pesticide registration(Agricultural Industry Standard of the People's Republic of China). Conclusion The molluscicidal efficacy by immersion method using 50% WPNES under low temperature in winter season can meet the requirements of the industry standard, whereas the effect under field conditions needs to be further verified.

Key words: Niclosamide, Immersion method, Winter, Oncomelania hupensis

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