热带病与寄生虫学 ›› 2015, Vol. 13 ›› Issue (3): 139-142,171.doi: 10.3969/j.issn.1672-2302.2015.03.005

• 论著 • 上一篇    下一篇

北京地区输入性疟疾血细胞及生化检验指标变化的敏感性分析

邹洋*,魏巍# ,李小丽,王磊,王非,李威,齐志群,田小军   

  1. 100050  北京市,首都医科大学附属北京友谊医院 北京热带医学研究所、热带病防治研究北京市重点实验室(邹洋、李小丽、王磊、王非、李威、齐志群、田小军、安亦君、李晶晶、黄敏君、谷俊朝),首都医科大学附属北京友谊医院临床流行病学与循证医学中心(魏巍)
  • 出版日期:2015-09-10 发布日期:2015-09-30
  • 基金资助:

    北京市科委首都临床特色应用研究专项资助项目(Z20130309020037),国家临床重点专科建设项目资助,热带病防治研究北京市重点实验室开放课题项目资助

Determination of the hemocytology and blood biochemical parameters in imported malarial patients in Beijing areas

Zou Yang*, Wei Wei#, Li Xiaoli, Wang Lei, Wang Fei, Li wei, Qi Zhiqun, Tian Xiaojun, An Yijun, Li Jingjing, Huang Minjun, Gu Junchao   

  1. Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University.   Clinical Epidemiology and Evidence-based Medicine Center, Beijing Friendship Hospital.   Beijing 100050, China.
  • Online:2015-09-10 Published:2015-09-30

摘要: 【摘要】 目的  分析输入性疟疾患者确诊前的各项血、尿常规和血生化等检查指标,探讨各检测参数指标的临床早期诊断方面的意义。 方法  使用SPSS 18.0软件,回顾性分析55例临床确诊输入性疟疾患者的各项血、尿常规和血生化等检查指标, 并建立正常对照组。采用Logistic 多元回归分析, 初步完成输入性疟疾各检验参数指标的分析。 结果  血常规中血小板减少(OR=0.980,P=0.003),肝功能中谷草转氨酶升高(OR=0.969,P=0.013),和尿素氮的变化(OR=1.907,P=0.013),在疟疾早期各生化指标变化中具有明显意义。 结论  通过本次研究,初步表明血常规中血小板减少,肝功能中谷草转氨酶升高,和尿素氮的变化,在疟疾早期各生化指标变化中具有明显意义。其综合判断,有利于输入性疟疾诊断早期预警,降低误诊率,提高诊断率。对疟疾的临床早期诊断具有重要意义。

关键词: 输入性疟疾, 常规指标, 早期预警, 多元分析, 北京

Abstract:

【Abstract】 Objective  To investigate the clinical significance by determining the biochemical indicators on urine and blood for early diagnosis of imported malarial patients. Methods  The parameters of urine and blood biochemistry were retrospectively analyzed in 55 clinically confirmed patients with imported malaria in Beijing area with multiple Logistic regression by using software SPSS 18.0, and the results were compared with health controls. Results The biochemical parameters, including decreased blood platelet(OR=0.980, P=0.003), elevated glutamic-oxaloacetic transaminase(OR=0.969, P=0.013) and blood urea nitrogen(OR=1.907, P=0.013), were statistically significant in early stage of infection in imported malarial patients. Conclusion  Biochemical parameters changed significantly in the early stage of infection in patients of imported malaria, suggesting that determination of these indicators can lead to early diagnosis and treatment of this disease.

Key words: Imported malaria, Biochemical parameters, Early diagnosis, Logistic analysis, Beijing