关键词: 华支睾吸虫病, 吡喹酮, 门诊治疗, 疗效

Abstract: Objective To explore the clinical efficacy of praziquantel in the treatment of outpatients with clonorchiasis for evidence in routine deworming regimen on outpatient basis. Methods 2 241 patients with clonorchiasis treated in the clinic of Parasitic Disease Prevention of Wuming District were included from January 2018 to December 2020. The treatment regimen consisted of a total dosage of 7 200 mg praziquantel orally used in 9 doses over 3 days,together with cholagogic tablets, liver-protecting tablets and vitamin B6 pills as well as other adjuvant drugs. Then the therapeutic effects and side effects were observed and analyzed. Results The reduction rate of eggs was 100. 00%(2 241 / 2 241) in fecal examination of patients infected with Clonorchis Sinensis. The total negative conversion rate for the eggs was 98. 93% ( 2 217 / 2 241),and 99. 30%(2 124 / 2 139),91. 92%(91 / 99) and 66. 67%(2 / 3) for patients with mild,moderate and severe infection,respectively. There was significant difference in the negative egg conversion rate in patients with moderate and severe infection( χ2= 50. 660, P= 0. 001) . Clonorchis Sinensiseggs were not detected in the feces in patients with failed negative conversion medicated with added dose as previous regimen. The incidence of adverse drug reactions was 9. 15%,with nervous system being dominant,followed by digestive system. The symptoms were generally mild,and no serious adverse response occurred. Conclusion Medium-dose praziquantel can be effective,yet lower side effects in the treatment of patients on outpatient clinic basis in areas with Clonorchis sinensisendemic.

Key words: Clonorchiasis, Praziquantel, Outpatient therapy, Curative effect