热带病与寄生虫学

热带病与寄生虫学 ›› 2020, Vol. 18 ›› Issue (2): 127-131.

• 综述 • 上一篇    

肾综合征出血热与 HLA 基因多态性相关性研究进展 

刘淦1,杨进孙2∗,孙恩涛1∗
  

  1. 1. 皖南医学院检验学院,芜湖,241002; 2. 皖南医学院弋矶山医院
  • 出版日期:2020-06-10 发布日期:2020-05-27
  • 通信作者: 孙恩涛，杨进孙 E-mail:asdentao@ 126. com，yangjinsun999999@ 163. com
  • 作者简介:刘淦,男,本科在读,研究方向:病原微生物学
  • 基金资助:
    国家自然科学基金项目(31870352);皖南医学院 2019 年青年卓越人才资助项目( Wyqnyx201902);皖南医学院大学生科研基金项目(WK2019S19);安徽省省级大学生创新创业项目(201810368140)

Research progress in patients of hemorrhagic fever with renal syndrome and HLA gene polymorphism

LIU Gan1, YANG Jin-sun2∗, SUN En-tao1∗    

  1. 1. School of Laboratory Medicine, Wannan Medical College, Wuhu 241002, China; 2. Department of Infectious Diseases, Yijishan
    Hospital of Wannan Medical College
  • Online:2020-06-10 Published:2020-05-27

PDF (PC)

1370

摘要： 肾综合征出血热( Hemorrhagic fever with renal syndrome,HFRS) 是源于动物感染的自然疫源性疾病,HFRS 的发病机制受多因素共同调控,其中病原免疫性因素在 HFRS 中起主导作用。 研究发现 HFRS 与人类白细胞抗原(Human lymphocyte antigen,HLA)基因多态性关系密切,HFRS 遗传相关性及病程严重度在一定水平上受 HLA基因多态性影响。 本文就 HFRS 与 HLA 基因多态性的相关研究进展作综述,为临床早期筛查诊断 HFRS 及评估发病风险提供科学依据。

关键词: 人类白细胞抗原, 多态性, 肾综合征出血热, 相关性, 进展

Abstract: Hemorrhagic fever with renal syndrome ( HFRS) is a natural focus disease originated from animal infection. The pathogenesis of HFRS is controlled by many factors, in which the pathogenic immune plays a major role. Studies demonstrated that HFRS was closely connected with human leukocyte antigen(HLA) gene polymorphism, and the genetic correlation and course severity of HFRS were affected by HLA gene polymorphism at a certain level. This paper aims at reviewing the research progress in HFRS and HLA gene polymorphism in order to provide a scientific basis for early clinical screening and diagnosis of HFRS as well as assessment of the disease risks.

Key words: Human leukocyte antigen, Polymorphism, Hemorrhagic fever with renal syndrome, Correlation, Progress

中图分类号: